Background: A cloud-based, multifunction, bidirectional app that communicates real-time patient-reported cancer treatment symptom(s)/severity and clinical care team (CCT) recommendation(s) can lessen treatment burden. Additionally, it can be used creatively to enhance operational efficiency by replacing appointment scheduling via phone with a templated message sent using the secure communication feature. Methods: Four different datasets were analyzed for this multimethod study. In the first, an independent sample t-test was used to compare the time it took to review a patient record and contact them via phone with post-app implementation, which included the same review and scheduling an appointment by templated message using the app’s secure communication feature. Second, the tasked nurse was interviewed for 30 minutes to solicit her opinion regarding this new workflow. Third, a clinic survey assessing patient preference for communication (phone call vs. secure communication via app) was analyzed descriptively. Finally, patient satisfaction with the app was assessed by randomly asking users with active accounts for a minimum of 30 days, “How likely are you to recommend “the app” to another patient?”. Patients answered the question using an 11-point visual analog scale. Data collected over 180 days (downloaded June 21, 2023) were analyzed descriptively. Results: There was a significant difference in the time required for the nurse to schedule appointments (t=5.4, p<0.01); patient contact by app took much less time (n=89; M=7.1 minutes; SD=2.8) than pre-implementation phone calls (n=55; M=11.7 minutes; SD=6.0). During the interview, the nurse found that setting up the new workflow was “tricky and time-consuming...but benefits for both yourself and your patient completely outweigh the stress and the hard work it took you to get to that point“. Additionally, she noted increased efficiency, “It's most definitely made it easier to run the clinic. For instance, the nine patients yesterday...if I had done a phone clinic that would have taken me the whole morning, whereas it took me about an hour and a half, I think, to do those nine patients.” In her view, this new approach did not negatively impact patient care, “I don’t think doing it this way is compromising care in any way.” Third, the survey (n=66) indicated that, generally, patients found app-based communication better (n=35; 53.0%) than phone-based (n=13; 19.7%). Finally, patients’ (n=228) mean overall app satisfaction was 8.5 (SD=2.4); 65.4% rated it a 9 or 10. Conclusions: Novel use of an ePRO’s secure communication feature has – quantitatively and qualitatively – demonstrated greater operational efficiencies. Further, most patients favored this contact modality and rated the app highly.