Background: Based on national OAM guidelines and to improve patient safety, most OAM programs monitor toxicity/adherence within 10-14 days following OAM initiation. At our institution, only 50% of toxicity/adherence documentation tasks were completed by day 10 of cycle 1 after initiating OAM. We aimed to increase toxicity/adherence documentation tasks to at least 75% by day 10 of cycle 1 following a newly prescribed OAM in collaboration with Hematology/Oncology Pharmacy Association/American Society of Clinical Oncology 2022 quality training program (QTP). Methods: We engaged a multidisciplinary team to gather/interpret data, create process map, and identify barriers. Outcome measure was documentation of toxicity/adherence by day 10 of cycle 1. Included all cancer patients initiating OAM treatment plan. Excluded those on intravenous/oral regimens and gynecology/oncology patients. Process measure was percentage of 9 crucial tasks identified as necessary to appropriately document toxicity/adherence. Balance measures included provider visits, emergency department visits, telephone/electronic medical record OAM-related messages, and nursing satisfaction. A cause-and-effect diagram, pareto chart and prioritization matrix were used to narrow focus of improvement changes. Two plan-do-study-act (PDSA) cycles were conducted from January 2023-June 2023. All data were analyzed using Statistical Process Control Charts with 3-sigma control limits. Results: Original high-impact, easy-to-implement intervention (re-training staff) delayed due to institutional-directed intervention (education documentation retraining due to The Joint Commission survey). Education documentation retraining did not significantly improve toxicity/adherence task completion rate (50% to 53%) by improved provider and emergency department visits (16.7% and 12.5% to 0%) (see Table 1). Nursing turnover, lack of formal OAM process training and institutional buy-in for OAM program/training likely contributed to results. Re-training supported with institutional buy-in completed. PDSA cycle 2 data collection is ongoing; preliminary results show no change in task completion rate. Conclusions: Education documentation and retraining alone is insufficient to improve OAM toxicity/adherence documentation rates. Other interventions are needed to attain our goal.