Manipal Comprehensive Cancer Center, Bangalore, India
S.P. Somashekhar , Rohit Kumar C. , Ashwin K. Rajgopal , Amit Rauthan , Poonam Patil , Priya Kapoor
Background: The primary objective of this study is to assess Qol & response rates in platinum resistant ovarian cancer patients with peritoneal metastasis treated with PIPAC procedure in comparison with conventional systemic intravenous chemotherapy. Methods: Between October 2017 and December 2019, 31 PIPAC applications were done in 15 patients with cisplatin 10.5mg/m2 and doxorubicin 2.1mg/m2. During same period 20 patients received systemic chemotherapy with clinician’s choice of drug ((mono-therapy consisting of pegylated liposomal doxorubicin or topotecan or gemcitabine or paclitaxel weekly with or without bevacizumab).The response rate (With MRI & Ca-125) & quality of life assessment (QLQ C-30) of both the group was done periodically and recorded. Results: Overall 35 patients were analysed in this study. The results have been presented in Table. Conclusions: PIPAC in comparison to intravenous chemotherapy for platinum resistant ovarian cancer with peritoneal metastasis showed better response rates (66.6 vs. 22.4%) and improved quality of life score. PIPAC has shown promising results and should be in the arsenal of the clinicians managing patients with platinum resistant ovarian cancer.
PIPAC N = 15 | IV Chemo (N = 20) | |
---|---|---|
Age (years) | 55.5 ± 9.4 | 54.3± 6.7 |
ECOG | ||
0 | 3 | 5 |
1 | 8 | 12 |
2 | 4 | 3 |
Previous Surgery | ||
1 | 7 | 14 |
2 | 8 | 06 |
Systemic Chemotherapy | ||
2nd line | 8 | 12 |
> 2nd line | 7 | 08 |
Number of Cycles Intervention | Total = 31 | |
3 cycle = 4 | 6 cycle = 5 | |
2 cycle = 8 | 4 cycle = 10 | |
1 cycle = 3 | 3 cycle = 5 | |
Serum CA 125 IU/ml | 220± 15.4 | 235± 12.7 |
PCI | 23.5± 8.7 | 18.4± 7.5 |
Over all Response rate | 66.6% | 22.4% |
Overall Morbidity (G3-G4) | 15.3% | 33.3% |
Overall QOL | ||
Day 0 | 62 | 63 |
Day 60 | 65 | 60 |
Day 120 | 71 | 57 |
Day 180 | 78 | 54 |
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Abstract Disclosures
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First Author: S.P. Somashekhar
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