Paradoxical survival of Hispanics with colorectal cancer: SEER-based cohort.

Authors

null

Mahmoud Chaker

Wayne State University School of Medicine, Detroit, MI

Mahmoud Chaker , Anas M Saad , Muneer J Al-Husseini , Mohamed M Gad , Ahmad Rachid , Asfar S. Azmi

Organizations

Wayne State University School of Medicine, Detroit, MI, Ain Shams University, Cairo, Egypt, Faculty of Medicine, Ain Shams University, Cairo, Egypt, Cairo, Egypt, Karmanos Cancer Institute, Detroit, MI

Research Funding

Other

Background: Hispanic populations in the United States are historically underserved with less access to health care as well as lower quality of the provided medical care. With the Colorectal Cancer (CRC) being the third most common cancer in both men and women in the United States, studies were lacking at comparing the survival of Hispanics to non-Hispanics. We aim to study the survival of Hispanic patients with CRC. Methods: We got 547,108 with CRC, of which 42,712 were Hispanics diagnosed between 1973 and 2014 from the SEER database. We calculated the overall and colorectal cancer-specific survival of Hispanics, and non-Hispanics, using unadjusted Kaplan-Meier test and multivariable covariate-adjusted Cox models. Results: The median overall survival of Hispanics was 81 months (95% CI, 78.602- 83.398) and was significantly higher (p < .001) than the overall survival of non-Hispanics; 59 months (95%CI, 58.548- 59.452). Colorectal cancer-specific survival followed a similar trend and Hispanics had better survival outcomes. When we adjusted for age, sex, marital status, stage, grade, and surgery, non-Hispanics were associated with worse survival outcomes (HR = 1.119, 95%CI [1.097-1.140], p < .001). Adjusted cancer-specific survival followed the same trend, and non-Hispanics had worse outcomes (HR = 1.080, 95%CI [1.052-1.108], p < .001). Conclusions: Hispanics with CRC have better overall survival as well as colorectal cancer-specific survival than non-Hispanics. Further studies are required to evaluate the underlying socioeconomic, nutritional, and/or genetic differences contributing to the disparities in survival and the superior survival in Hispanic patients.

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Abstract Details

Meeting

2018 ASCO Annual Meeting

Session Type

Publication Only

Session Title

Publication Only: Gastrointestinal (Colorectal) Cancer

Track

Gastrointestinal Cancer—Colorectal and Anal

Sub Track

Epidemiology/Outcomes

Citation

J Clin Oncol 36, 2018 (suppl; abstr e15652)

DOI

10.1200/JCO.2018.36.15_suppl.e15652

Abstract #

e15652

Abstract Disclosures