Background: The IOM 2013 report recommends supportive oncology care starting at diagnosis and Commission on Cancer standard 3.2 requires distress screening and indicated care. Current screening tools are fragmented and address only a portion of patients’ supportive oncology needs. Integration in clinical flow can be burdensome. Screening and provision of supportive oncology care vary widely across institutions. Methods: A collaborative of 100+ clinicians, funded by The Coleman Foundation, developed a patient-centric consolidated screening tool based on validated instruments (NCCN Distress Problem List, PHQ-4, PROMIS), and IOM 2013 treatment and care concerns. 5 cancer centers piloted the tool and surveyed a sample of patients, providers assessing each patient’s screening results (assessors) and providers receiving referrals. Results: Responders included 29 patients, 81 assessors and 26 providers receiving referrals. A majority found that the tool asked the right questions, but some reported partial relevance (Table). However, 96% (25/26) of assessors reporting partial relevance also uncovered one or more relevant needs for the same patient (p = 0.002). 75% of patients completed the screening tool on their own, 12% with limited help, 5% did not have enough time, 4% could not complete and 3% declined. Completing the screening tool took 10 minutes or less for 78% of patients. The assessors spent less than 5 minutes reviewing the tool results for 76% of patients. 70% of patients would be willing to complete the tool at every visit. Conclusions: A consolidated supportive oncology screening tool is feasible, accepted by and beneficial for most patients and providers to identify distress and supportive oncology needs. As the tool is adopted by collaborating institutions, it is expected to reduce variation and increase consistency in supportive oncology screening and care with implications for national dissemination.