Treatment of Multiple Myeloma

Published online April 1, 2019, DOI:10.1200/JCO.18.02096

Joseph Mikhael, Nofisat Ismaila, Matthew C. Cheung, Caitlin Costello, Madhav V. Dhodapkar, Shaji Kumar, Martha Lacy, Brea Lipe, Richard F. Little, Anna Nikonova, James Omel, Namrata Peswani, Anca Prica, Noopur Raje, Rahul Seth, David H. Vesole, Irwin Walker, Alexander Whitley, Tanya M. Wildes, Sandy Wong, and Tom Martin

Purpose

To provide evidence-based recommendations on the treatment of multiple myeloma to practicing physicians and others.

Methods

ASCO and Cancer Care Ontario convened an Expert Panel of medical oncology, surgery, radiation oncology, and advocacy experts to conduct a literature search, which included systematic reviews, meta-analyses, randomized controlled trials, and some phase II studies published from 2005 through 2018. Outcomes of interest included survival, progression-free survival, response rate, and quality of life. Expert Panel members used available evidence and informal consensus to develop evidence-based guideline recommendations.

Results

The literature search identified 124 relevant studies to inform the evidence base for this guideline.

Recommendations

Evidence-based recommendations were developed for patients with multiple myeloma who are transplantation eligible and those who are ineligible and for patients with relapsed or refractory disease.

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