Background: Physical activity (PA) has been associated with improved QOL and survival in breast and colorectal cancer survivors, yet no study has examined the effect of exercise on ovarian cancer outcomes. The purpose of our NCI-funded trial is to examine, in 230 women diagnosed with Stage I-IV ovarian cancer, the impact of exercise vs. attention control on: QOL, body composition, and serum markers associated with ovarian cancer. This abstract presents preliminary recruitment and adherence results. Methods: Women are being recruited via Connecticut Tumor Registry and Yale Cancer Center into the Women’s Activity and Lifeclass Study in Connecticut (WALC). We are also recruiting patients nationally via self-referral and collaboration with medical oncologists at DFCI and Summa Akron City Hospital. Women are randomly assigned to exercise (n = 115) or attention control (n = 115). Both groups receive weekly telephone calls for six months from a certified health educator to discuss ovarian cancer health topics. In addition, the exercise group receives PA counseling to participate in 150 min/wk of aerobic exercise (primarily brisk walking) for six months. Results: Study recruitment began in March, 2010 and will be ongoing through December, 2013. As of December 31, 2011, we have identified 556 potentially eligible women. Of these, 145 are recently diagnosed and are awaiting screening, 115 were unable to be contacted, and 296 have completed the telephone screening. Of the 270, 46% were ineligible (e.g., already exercising, physical limitations); 30% were not interested, 24% (n = 66) have been randomized, and 9% (n = 24) are undergoing baseline visits. On average, women are 62 years old, diagnosed 1.8 years in the past, with primarily stage III disease. Thirty-three patients have completed the trial, with high adherence among women randomized to exercise (average 141 min/wk of exercise reported and 75% of exercisers participating in at least 150 min/wk of exercise). Conclusions: Women are interested in and able to participate in exercise after an ovarian cancer diagnosis. Our trial could suggest a unique and important role for exercise in ovarian cancer care given that physical and functional aspects of QOL are often the most compromised in ovarian cancer patients.