Background: Hispanic women in the US have a lower incidence but higher mortality from breast cancer (BC). Data is limited describing the disease in Hispanics. We describe our experience among BC patients (pts) in a county hospital serving an indigent population; majority of whom are of Hispanic ethnicity. Methods: Retrospective observational study, N=359 pts diagnosed with BC from 2005-2009. Metastatic disease and non-hispanic minority were excluded. Patient characteristics included demographics, pathology (histology, stage, grade and tumor size), hormone status (ER, PR and HER-2) and Rx (surgery, radiation (RT) and hormonal therapy). Pearson’s chi-square test and student’s t-test was used to compare categorical and continuous variables respectively. Results: Study cohort = 199 (79%) Hispanic (H) and 53 (21%) Caucasian (C). H were younger at diagnosis; mean age 50.4 vs 54.3 (C) (p=0.298). Most common histology was infiltrating ductal carcinoma. No significant difference in pathological charecteristics was noted. We observed higher % of hormone receptor + in H (ER+; 75 vs 68% and PR+; 70 vs 66%). HER-2 + was higher in the H (16 vs 14.5%). Triple negative (TN) BC was higher in the H (20 vs 11%, p=0.28). Higher % of H had surgery (86 vs 74%; p=0.03); however, fewer H received RT after lumpectomy (22 vs 47%; p=.01) In premenopausal pts a higher % of H received tamoxifen (45 vs 27%; p =0.27). A higher % of AI use was noted in the post menopausal H (27 vs 22%; p=0.58). Screening mammogram (SM): 69% had no SM. H vs C (73 vs 80%). Among the whole cohort 40% were lost to follow-up. Median follow-up was higher in H (29 vs 20 months, p=0.03). Mortality rates were not statistically significant (H vs C; 2 vs 3.7%). Conclusions: Prior studies report a higher mortality from BC among H vs C women. However, our analyses from a large county hospital demonstrated statistically similar mortality rates in H compared to C. This is despite H presenting earlier and having more TN tumors. This observation could be attributed to similar socioeconomic status in these patients irrespective of ethinicity seeking care in this county hospital. Larger studies need to be done to tease out biological vs. socioeconomic influences in the mortality related to BC among Hispanic women.