Background: Lung cancer is the leading cause of cancer-related death in the United States. Previous studies have suggested that patients with lung cancers are at increased risk of cardiovascular comorbidities that increase the risk of death in these patients. We studied the disparities in the prevalence of heart failure and risk factor analysis in lung cancer patients. Methods: We utilized the National Inpatient sample (2019-2020) to identify the patients who were admitted with a primary diagnosis of lung cancer (local/regional + advanced metastatic disease) and had a concurrent diagnosis of Heart Failure (HF). Baseline demographic characteristics were analyzed to determine the disparities in the prevalence of HF in lung cancer patients. Multivariate logistic regression analysis was done to assess the association of heart failure with lung cancer. Results: A total of 221320 patients had lung cancer, and 25495 had concurrent HF. The mean age of patients with and without HF was 73 and 68, respectively, p<0.001. HF patients had a greater percentage of males than females (55% vs 44%, P<0.001). Female patients were less likely to have HF (OR=0.82(0.77-0.88), p<0.001), and older age was associated with increased risk of HF in lung cancer patients (46-64 years, OR=8.23(1.13-59.49), p=0.03, >65 years OR=15.08(2.07-109), p=0.007). In Lung cancer patients hyperlipidemia had the greatest risk of association with HF (OR=1.85(1.71-1.99), p<0.001), followed by obesity (OR=1.78(1.60-1.99), p<0.001), Diabetes (OR=1.70(1.56-1.85), p<0.001), End stage renal disease (OR=1.61(1.25-2.06), p<0.001) and COPD(OR=1.45(1.34-1.56), p<0.001). Hypertension was associated with decreased odds of HF (OR=0.01(0.01-0.015), p<0.001). Compared to the white population, the Black race had increased odds of association with HF (OR=1.40(1.25-1.56), p<0.001). Compared to Medicare, patients with Medicaid and private insurance were less likely to have HF (OR 0.76(0.65-0.89), p=0.001; OR=0.59(0.52-0.66), p<0.001, respectively). Patients in high-income groups had decreased likelihood of concurrent HF ($65,000-$85,999, OR=0.88(0.80-0.98), p=0.02 and >$86,000, OR=0.88(0.78-0.99), p=0.04). Conclusions: Lung cancer patients of Black race, older age, and those with medicare insurance are at a higher risk of developing heart failure. The presence of hyperlipidemia, obesity, diabetes, end-stage renal disease, and COPD is considered to be among the most significant risk factors for the development of heart failure in lung cancer patients. Addressing underlying risk factors can enhance patient outcomes and promote overall quality of life in patients with lung cancer.