Preliminary data from a dose-escalation phase 1 study with HP518, an AR PROTAC degrader: Safety, tolerability, pharmacokinetics (PK), and first assessment of anti-tumor activity in patients (Pts) with metastatic castration-resistant prostate cancer (mCRPC).

Authors

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Arun Azad

Peter MacCallum Cancer Centre; and Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia

Arun Azad , Howard Gurney , Craig Underhill , Lisa Horvath , Mark Voskoboynik , Xinghai Li , Ivan King , Lisa Shao , Yiyun Dai , Frank Perabo

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Poster Details

Meeting

2024 ASCO Genitourinary Cancers Symposium

Session Type

Poster Session

Session Title

Poster Session A: Prostate Cancer

Track

Prostate Cancer - Advanced,Prostate Cancer - Localized

Sub Track

Therapeutics

Clinical Trial Registration Number

NCT05252364

Citation

J Clin Oncol 42, 2024 (suppl 4; abstr 124)

DOI

10.1200/JCO.2024.42.4_suppl.124

Abstract #

124

Poster Bd #

E17

Abstract Disclosures