Background: Clinical trials are integral to cancer care but face frequent accrual challenges as they grow numerous and complex. Artificial intelligence (AI) technologies can cognitively aid oncology providers, but few have rigorously been evaluated or optimally integrated into clinical workflow. We developed an AI-powered mobile application, LookUpTrials, to support oncology providers in facilitating point-of-care access to relevant information on cancer clinical trials. This study examines user engagement of LookUpTrials among oncology providers. Methods: LookUpTrials functions as a search engine for clinical trials. Unlike traditional trial registries, LookUpTrials provides an open forum, similar to a social media platform, to allow users to update information (i.e., trial availability) and share knowledge (i.e., clinical experience) about clinical trials. Additionally, LookUpTrials leverage Al technologies supported by Apple Inc. and ChatGPT to assist with summary and search queries. Similar applications exist, but few support real-time update, editable by clinical trial teams. On Feb 27^th, 2022, we piloted LookUpTrials in the Head and Neck and Breast medical oncology services at the Memorial Sloan Kettering Cancer Center (MSK). Leveraging Google Firebase and Apple Analytics, LookUpTrials prospectively auto-captured user engagement measures. Measurement included: 1) sessions: instances when users opened app or viewed an app screen; 2) engaged sessions: sessions that lasted longer than 10 seconds or had 2 or more screen views; and 3) engagement time: time that app ran in the foreground. We applied market segmentation and descriptive statistics to analyze the measures. Results: In 2022, LookUpTrials received 166 downloads, the majority within the United States (73%), a few unknown (7%), and others across 8 countries, including China (9%), Ukraine (5%), Egypt (1%), France (1%), Morocco (1%), Switzerland (1%), Turkey (1%), and the United Kingdom (1%). Within the MSK pilot, LookUpTrials provided information on over 80 trials, including trials on breast cancer, head and neck cancers, thyroid cancers, salivary gland cancers, and non-melanoma skin cancers. Among 115 active users (72% of downloads), the application recorded 1,115 engaged sessions (68% of sessions), averaging 10 engaged sessions per user and an engagement time of 39 minutes and 8 seconds. Conclusions: LookUpTrials demonstrated promising user engagement among oncology providers. As the number and complexity of cancer clinical trials expand, future studies are needed to evaluate the optimal process to integrate LookUpTrials into cancer care delivery and to understand its effects in supporting providers in trial accrual.