Background: Hyponatremia has historically been reported to increase mortality and length of stay in hospitalized patients with solid tumors. There are sparse reports of hyponatremia linked to Pancreatic cancer in the published literature. Therefore, we evaluated mortality, morbidity, and resource utilization in Pancreatic cancer patients secondary to hyponatremia. Methods: A retrospective analysis was performed by utilizing the National Inpatient Sample database 2019 and the ICD- 10 codes to identify the patients > 18 years old with the principal diagnosis of Pancreatic cancer. Effect of hyponatremia was studied on mortality, morbidity, and resource utilization. Categorical variables were compared using the chi-square test, and continuous variables were compared using the t- test. Multivariable regression analyses were performed adjusting for demographics, hospital-level characteristics, and relevant comorbidities. Confounding variables were adjusted using multivariate logistic and linear regression analyses. These included: gender, race, Charlson Comorbidity Index, chronic kidney disease, congestive heart failure, cirrhosis, nephrotic syndrome, hypothyroidism, alcohol use disorder, and various patient and hospital characteristics. Results: We identified a total of 110,980 patients with primary diagnosis of pancreatic cancer in 2019, Of whom 18.1% (5,845) had hyponatremia on presentation. Patients with hyponatremia had 9.48 % in-hospital mortality, while 6.68% for patients without hyponatremia. After adjusting for confounders, hyponatremia imparted higher odds of mortality (Adjusted odds ratio (aOR) for mortality 1.46, 95% confidence interval (CI): 1.28–1.67, P< 0.01). Pancreatic cancer patients with hyponatremia have higher odds of Sepsis (Odd ratio = 1.64), Acute kidney injury (Odd ratio = 2.03), Peritonitis (Odd ratio = 2.40), and ICU admission (Odd ratio = 3.82). Hyponatremia also resulted in higher resource utilization marked by the length of stay, and hospital charges, (higher mean LOS by 1.16 days, and higher mean total hospital charges by $ 12,320). Conclusions: Hyponatremia in Pancreatic cancer patients had a prevalence of 18.1% and resulted in increased in-hospital mortality. Whether time-efficient treatment of hyponatremia would help reduce mortality and improve outcomes remains to be determined in future studies.