Background: Multidisciplinary teams (MDTs) are helpful in making clinical decisions and improving patients’ care. This study aims at describing the situation in the Arab world, probing the logistics of cancer patients' referral to MDTs, and highlighting the challenges facing them. Methods: This cross-sectional study via an online pre-tested self-administered survey targeted oncologists and non-oncologists across the Arab world. Results: The survey included 435 participants from 18 Arab countries (317 were oncologists and 118 were non-oncologists). Among the non-oncologists, 67% were involved in diagnosis and management of newly diagnosed cancer patients, 73.5% had specific patient referral criteria in their countries: upon suspected imaging (36%) or proved biopsy results (26%). However, only 36% discuss these patients regularly in MDTs, and 55 out of the 118 do not attend MDT clinics as 47% of them were not invited to MDTs and 13% have a diagnostic role only. Similarly, oncologists thought non-oncologists usually refer suspected patients to oncologists/MDTs upon: suspected imaging (52%), malignant biopsy results (48%), or both (43%). On the other hand, oncologists refer patients to non-oncologists either due to patients’ comorbidities (59%) or upon MDT decision (43%). The results indicated 57% of oncologists discuss suspected patients in MDTs. Among all MDT clinics attendants, 60% had recognized MDTs in their centers. Nevertheless, the majority do not have MDTs for all subspecialties. Moreover, 53% indicated that suspected patients are not directly referred to MDTs; and only 27% indicated they always manage cancer patients upon MDT decision. The majority agreed that surgical, radiation, medical or clinical oncology, radiology and pathology attend MDT clinics. Contrarily, only 5%, 11%, 10%, 2%, 16%, 10% and 13% indicated that psychiatry, nutrition, palliative care, physiotherapy, clinical pathology, specialized nurses and clinical pharmacy attend MDT clinics. Results showed also 94% thought patients benefit of MDTs. The participants’ main consensus upon MDTs benefit was providing accurate treatment recommendations (83%), better clinical decision (70%), and improving team competence (53%). The participants thought the challenges facing MDTs were mainly irregular attendance of physicians (55%), the large number of patients presented in MDTs (41%) and absence of some specialties in MDTs, which means referring patients directly to them (37%). Conclusions: Most institutes have MDTs, but they mainly discuss few subspecialties. Moreover, only 27% of the surveyed physicians indicated they always manage cancer patients upon MDT decision. Additionally, the majority indicated that mainly oncologists, radiologists, and pathologists attend the MDTs. However, other specialties are sorely underrepresented. These discrepancies between MDT logistics through the Arab Countries are deemed a challenge to MDT practice and patient outcomes.