Background: Lung cancer is the leading cause of cancer mortality in the United States and has a higher mortality rate in men. While most patients are typically elderly adults, research shows that rates of lung cancer among younger patients have been increasing. Furthermore, younger patients with lung cancer have unique clinicopathologic characteristics. Methods: A total of 139 lung cancer patients (59 Male and 80 Female) who were under the age of 45 and treated at the University of Miami between 2012-2021were included. Demographics and clinicopathologic characteristics were analyzed. Results: The median age at diagnosis for female and male patients was 39.6yrs vs 38.4yrs. (Table 1) Among females, 28% were White non- Hispanic (NH), 47% were White Hispanic, 8% were Black NH, 2% were Black Hispanic and 11% were of other race. Among males, 38% were White non- Hispanic (NH), 44% were White Hispanic, 8% were Black NH, 5% were Black Hispanic and 3% were of other race. While 67% of male patients smoked tobacco, only 43% of female patients endorsed a history of smoking tobacco (p = 0.005). Male patients underwent surgery after an average of 22 days from diagnosis compared to 17 days for female patients. Moreover, 40% of females had surgical resection compared to 29% of males. The average number of days between a positive biopsy and initiation of chemotherapy for male vs female patients was 39 days vs 36 days, respectively. Female patients had higher trends of adenocarcinoma (68%) and actionable mutations (62%) than their male counterparts (44% and 42%). Lastly, they had lower trends of metastatic disease at diagnosis (58%) than male subjects (62%). Conclusions: Lung cancer trends in older adults appear to remain consistent in younger patients. Young male patients smoke cigarettes significantly more than young female patients. While no other statistically significant differences were found, our study noted a few trends. Overall, females presented with localized disease at a higher rate and had a higher percentage of actionable mutations. Male patients appeared to be more likely to present with systemic disease, which reduced the opportunity for surgical resection. Further prospective studies will be of paramount importance to explore these trends in large cohorts.