Background: Safety and quality improvement requirements are a part of the core competencies for ACGME-accredited hematology/oncology fellowships. The morbidity and mortality conference (MM) is a tool that has been used to identify safety issues and areas for improvement. The traditional format primarily includes an audience of clinicians. We sought to develop an interactive, interprofessional MM (i-MM), including institutional leadership, physicians, fellows, residents, advanced practice providers, nursing, and pharmacy, while meeting the ACGME Core competencies for Patient Safety and Quality Improvement in Hematology and Medical Oncology. Methods: A pilot i-MM was designed to create an enriching, interprofessional discussion regarding patient safety and quality improvement. We implemented a Plan-Do-Study-Act (PDSA) design to create the i-MM model that map to the core competencies. The first session was focused on two mortality events in immunocompromised hosts that triggered the sepsis bundle, one of which was due to toxic megacolon. The i-MM objectives were aligned with ACGME hematology/oncology fellowship requirements of quality and safety. The effectiveness of the pilot session was gauged via an anonymous post-session survey using a 4-point Likert scale. Results: A total of 32 people attended the pilot i-MM, including quality and safety leaders, faculty, fellows, medical residents, pharmacy, and nursing. A total of 10 participants across professions completed the post-i-MM survey. The survey demonstrated an average of 3.8/4 for all interprofessional educational goals, which included demonstration of mutual respect between healthcare professionals, engaging in effective interprofessional communication, and working within an interprofessional team. Content-specific aspects of the survey were rated with an average effectiveness of 3.60/4. Feedback on the survey recommended limiting i-MM to one case presentation instead of multiple. During the debrief session, it was reported that several nurses felt the moderated session was “inclusive and empowering”. Conclusions: The i-MM was an effective approach to meeting ACGME requirements for safety and quality learning objectives while creating an inclusive environment for all team members. Future PDSA cycles will continue to map i-MM learning objectives to ACGME hematology/oncology fellowship program core competencies in Section VI.A.1 and the section on Professionalism. Core competency mapping will guide future presentations that address issues on quality, safety, and health care disparities. Specific presenters and moderators from different professions will be chosen to lead each i-MM, with the goal of examining each case from different perspectives to provide a holistic interprofessional view of delivering quality medical care to patients.