Association of C-MYC, MYC target gene, and unfolded protein response (UPR) expression with clinical benefit from the oral aurora kinase A (AURKA) inhibitor, alisertib (A), in combination with paclitaxel (P) compared with P alone in patients (Pts) with HER2-negative metastatic breast cancer (MBC).

Authors

null

Sara A. Byron

Integrated Cancer Genomics Division, Translational Genomics Research Institute, Phoenix, AZ

Sara A. Byron , Jiaming Zhang , Tyler Izatt , Srishti Rajeev , George Reid , Daniel Enriquez , Bryce Turner , Yaden Santana , Danielle Vasquez , Shukmei Wong , Jonathan J. Keats , Joyce O'Shaughnessy

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Poster Details

Meeting

2023 ASCO Annual Meeting

Session Type

Poster Session

Session Title

Breast Cancer—Metastatic

Track

Breast Cancer

Sub Track

Biologic Correlates

Clinical Trial Registration Number

NCT02187991

Citation

J Clin Oncol 41, 2023 (suppl 16; abstr 1037)

DOI

10.1200/JCO.2023.41.16_suppl.1037

Abstract #

1037

Poster Bd #

258

Abstract Disclosures

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