Obesity and triple negative breast cancer diagnosis among premenopausal women.

Authors

Caitlin Taylor

Caitlin Taylor

Ochsner Medical Center, New Orleans, LA

Caitlin Taylor , Melanie Anne Sheen , Rabia Cattie , Victoria Chung , Marcia Henry , Susan Olet , Matthew Alberti , Helen Yuan , James Peeples , Raina Saxena

Organizations

Ochsner Medical Center, New Orleans, LA, Ochsner Health System, New Orleans, LA, Ochsner Clinic Foundation, New Orleans, LA, Ochsner Health, New Orleans, LA

Research Funding

No funding received
None.

Background: Obesity is a known risk factor for the development of postmenopausal breast cancer, specifically hormone-receptor positive breast cancer, and is associated with poor outcomes and decreased overall survival. While obesity in pre-menopausal patients is thought to be protective against the development of breast cancer, application across breast cancer subtypes remains less clear. Methods: We performed a retrospective analysis of 758 patients under 40 years of age diagnosed with breast cancer at our institution over 10 years. Variables including age at diagnosis, breast cancer subtype, race and BMI were evaluated. To assess the association between body mass index (BMI), race and triple negative breast cancer (TNBC), odds ratios (OR) and their associated 95% Confidence interval (CI) OR are reported. Results: Obese patients (BMI >30) were more likely to have TNBC compared with non-obese patients [OR=1.46, 95% CI [1.07 – 2.00), P=0.0161]. Black patients had a twofold likelihood of having TNBC compared with white patients regardless of BMI [OR=2.16, 95% CI [1.56 – 2.97), P<0.0001]. Conclusions: Obese patients under 40 years of age were more likely to be diagnosed with TNBC than non-obese patients. Our data highlights ongoing disparities among TNBC diagnosis and emphasizes the importance of weight loss interventions targeted towards premenopausal women at high risk for breast cancer.

Triple Negative
Yes N=231 (%)No N-527 (%)Total N=758P valueOR (95% CI)
BMI0.01611.46 (1.07-2.00)
BMI >30116 (35.0)215 (65.0)331
BMI ≤ 30115 (26.9)312 (73.1)427
Yes N= 225 (%)No N= 508 (%)Total N=733 (%)
Race<0.00012.16 (1.56-2.97)
Black112 (41.2)160 (58.8)272 (37.1)
White113 (24.5)348 (75.5)461 (62.9)

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Abstract Details

Meeting

2023 ASCO Annual Meeting

Session Type

Publication Only

Session Title

Publication Only: Prevention, Risk Reduction, and Hereditary Cancer

Track

Prevention, Risk Reduction, and Genetics

Sub Track

Cancer Prevention

Citation

J Clin Oncol 41, 2023 (suppl 16; abstr e22513)

DOI

10.1200/JCO.2023.41.16_suppl.e22513

Abstract #

e22513

Abstract Disclosures

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