Primary retroperitoneal lymph node dissection (RPLND) in seminoma stage IIA-IIC ≤3cm: Combined results of the SWENOTECA (Swedish Norwegian Testicular Cancer Group) and Cologne.

Authors

null

Torgrim Tandstad

St. Olav's University Hospital, Trondheim, Norway

Torgrim Tandstad , Anders Kjellman , Bjarte Almås , Anna Grenabo Bergdahl , Gabriella Elisabeth Cohn-Cedermark , Axel Gerdtsson , Ingrid Glimelius , Dag L. Halvorsen , Hege Sagstuen Sagstuen Haugnes , Annika Hedlund , Asa Karlsdottir , Signe Melsen Larsen , Helene F. S. Negaard , David Pfister , Olof Stahl , Anna Thor , Rolf Wahlquist , Axel Heidenreich , Pia Paffenholz , Felix Seelemeyer

Organizations

St. Olav's University Hospital, Trondheim, Norway, Department of Urology, Karolinska University Hospital, Huddinge, Stockholm, Sweden, Dept. of Urology, Haukeland University Hospital, Bergen, Norway, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, Karolinska Institutet, Stockholm, Sweden, Lund University, University Hospital UMAS, Malmö, Sweden, Uppsala University and Akademiska sjukhuset-Blod-och tumorsjukdomar, Uppsala, Sweden, St. Olavs University Hospital, Trondheim, Norway, Department of Oncology, University Hospital of North Norway, Tromso, Norway, Sahlgrenska University Hospital, Gothenburg, Sweden, Department of Oncology, Haukeland University Hospital, Bergen, Norway, Oslo University Hospital, Oslo, Norway, Department of Urology, University Hospital of Cologne, Cologne, Germany, Skåne University Hospital, Lund, Sweden, Karolinska University Hospital, Stockholm, Sweden, Dept. of Urology, University Hospital Cologne, Cologne, Germany

Research Funding

Other
Public health care in Norway and Sweden

Background: Chemotherapy or radiotherapy have been standard treatment for stage II seminomas with excellent survival but are associated with significant long-term treatment-related toxicities. Several prospective trials have shown primary retroperitoneal lymph node dissection (RPLND) to be an effective and safe alternative. The current SWENOTECA treatment program recommends primary RPLND in seminoma stage IIA to IIB ≤ 3 cm with 1-2 metastatic nodes as the standard treatment modality. We present preliminary results combined with data from Cologne. Methods: Within SWENOTECA, RPLND is centralized to 5 hospitals and Cologne is a tertiary centre for patients recruited from different parts of Germany. Both patients with recurrence after initial stage I disease and patients with primary stage IIA and IIB at diagnosis were included. We collected information on operation time, bleeding, peri- and postoperative complications. We also analyzed histologic outcome and whether adjuvant chemotherapy was given. We followed the patients for any recurrence of disease. Results: We have included 94 patients operated from May 2018 to November 2022. The number of operations per site varied from 4 to 28. The mean age of patients at time of RPLND was 41.8 years (range 21-79). Overall, 54 patients had recurrence after initial stage I disease and 40 patients had primary stage IIA/IIB disease at diagnosis (one missing data). At time of RPLND 62 patients had IIA-disease and 31 stage IIB-disease (one missing data). The histology from RPLND showed seminoma in 83 patients, benign/necrosis in eight patients, vital non-seminomatous GCT in one patient, teratoma only in one patient and lymphoma in one patient. Mean number of resected nodes was 19, and mean number of positive nodes were 1.5. Twenty-six patients (28%) were operated with robotic laparoscopic technique. Ten patients (10.6%) had a Clavien-Dindo postoperative complication > 2. Twenty-three of the patients were given adjuvant oncological treatment after RPLND, most of them one course of BEP. The patients have been followed for in median 18 months (range 2-59). Nine patients (9.6 %) have had recurrences, all but one in the first year after RPLND. Conclusions: Our early results of primary RPLND of seminomas IIA-IIB ≤ 3 cm are promising. Longer follow-up is required to ensure this as a safe treatment option.

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Abstract Details

Meeting

2023 ASCO Annual Meeting

Session Type

Oral Abstract Session

Session Title

Genitourinary Cancer—Prostate, Testicular, and Penile

Track

Genitourinary Cancer—Prostate, Testicular, and Penile

Sub Track

Germ Cell/Testicular Cancer

Citation

J Clin Oncol 41, 2023 (suppl 16; abstr 5008)

DOI

10.1200/JCO.2023.41.16_suppl.5008

Abstract #

5008

Abstract Disclosures

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