Prognostic role of HER2 expression in patients with ER-positive/HER2-negative breast cancer: Results from a population-based cancer registry study.

Authors

null

Antonino Musolino

Gruppo Oncologico Italiano di Ricerca Clinica (GOIRC), Parma, Italy

Antonino Musolino , Olga Serra , Benedetta Pellegrino , Chiara Tommasi , Daniele Zanoni , Laura Cortesi , Fabio Canino , Federico Piacentini , Paolo Sgargi , Maria Michiara

Organizations

Gruppo Oncologico Italiano di Ricerca Clinica (GOIRC), Parma, Italy, University Hospital of Parma, Parma, Italy, University of Parma, Parma, Italy, University Hospital Modena, Modena, MO, Italy, University Hospital of Modena, Modena, Italy

Research Funding

No funding received
None.

Background: Estrogen Receptor (ER)-positive (+)/Human Epidermal Growth Factor Receptor 2 (HER2)-negative (-) breast cancers (BCs) express variable protein levels of both ER and HER2, which can influence prognosis. Methods: We evaluated all invasive ER+/HER2- BCs (n = 3633) that were diagnosed and systematically collected by the Parma Province Cancer Registry, Italy, from 2004 to 2018. Tumors were classified by HER2 (IHC score of 0, 1+ or 2+ with negative FISH) and ER status (ER-low [1-9%], ER-moderate [10-79%] or ER-high [80-100%]). Comparisons of clinicopathologic characteristics and disease outcome were performed. Results: BCs with late-stage diagnosis (P = 0.04), high histologic grade (P< 0.0001), or high proliferative rate (P< 0.0001) were more likely HER2 2+/FISH-. The rate of ER-high BCs did not change from 2675 of 2938 (91%) HER2 0 tumors to 508 of 560 (90.7%) HER2 1+, and 124 of 135 (91.9%) HER2 2+/FISH- tumors. Correspondingly, ER-low BCs were not enriched among HER2 0 tumors compared to the other tumors with different HER2 expression (P = 0.6). The 5-year overall survival (OS) for HER2 2+/FISH- BCs was lower than that for HER2 0 or 1+ tumors (P = 0.03). ER-low/moderate tumors were associated with poorer OS in comparison with ER-high BCs (P< 0.0001). HER2 2+/FISH- status was detrimental to OS among patients (pts) with ER-high tumors (P = 0.04), while this finding was not observed among ER-low/moderate BCs (P = 0.21). An interaction between HER2 2+/FISH- expression and ER-high status was found for poorer OS after adjusting for prognostic variables (HR = 1.7; 95% CI: 1.1-2.9). Conclusions: The prognostic role of HER2 expression in pts with ER-positive/HER2-negative BCs seems to be restricted to ER-high tumors, while the worse prognosis of tumors with lower ER expression is not associated with HER2 status. These findings may help identify optimal patient inclusion criteria for clinical trials with novel anti-HER2 therapies in ER-positive/HER2-negative disease.

Disclaimer

This material on this page is ©2024 American Society of Clinical Oncology, all rights reserved. Licensing available upon request. For more information, please contact licensing@asco.org

Abstract Details

Meeting

2023 ASCO Annual Meeting

Session Type

Poster Session

Session Title

Breast Cancer—Local/Regional/Adjuvant

Track

Breast Cancer

Sub Track

Adjuvant Therapy

Citation

J Clin Oncol 41, 2023 (suppl 16; abstr 547)

DOI

10.1200/JCO.2023.41.16_suppl.547

Abstract #

547

Poster Bd #

377

Abstract Disclosures