Background: Our prior research shows that SGM cancer survivors experience high rates of depression, due in part to exposure to discrimination. Depression among cancer survivors in general has been linked to markers of systemic inflammation including peripheral blood interleukin (IL)-6, tumor necrosis factor alpha (TNFα), and C-reactive protein (CRP). To date, no studies have examined the association of these markers with depression among SGM cancer survivors in the context of discrimination. Methods: Cross-sectional patient-reported data and serum samples were collected from 66 SGM cancer survivors (see Table). Depression was assessed by the Patient Health Questionnaire (PHQ)-9, discrimination by the Harassment, Rejection, and Discrimination Scale (HHRDS), IL6 and TNFα by multiplex assay, and CRP by ELISA. We used a clinical cut-point for depression of 10 on the PHQ-9, indicating moderate depressive symptoms, and assessed associations between continuous variables using bivariate correlations and multivariate linear regressions. Results: More SGM cancer survivors exceeded the clinical cut-point for depression (15.9%) than cancer survivors in prior general population samples (11.3%). Higher depression among SGM cancer survivors was associated with higher levels of exposure to discrimination (r=0.28, p=0.03), TNFα (r=0.30, p=0.02), and CRP (r=0.39, p=0.002); exposure to workplace discrimination, specifically, was associated with higher levels of CRP (r=0.32, p=0.02). In multivariate models controlling for demographic and clinical characteristics, CRP remained a significant predictor of depression (β=0.34, p=0.01). Conclusions: This study replicates prior findings of high levels of depression among SGM cancer survivors. It provides preliminary evidence that markers of inflammation, specifically CRP, are uniquely predictive of depression among SGM cancer survivors in the context of exposure to discrimination. These findings need to be replicated in larger samples and evaluated for potential use in providing supportive cancer care to SGM survivors.