Use of circulating tumor DNA (ctDNA) to complement tumor tissue homologous recombination repair (HRR) gene alteration testing in TALAPRO-2, a phase 3 study of talazoparib (TALA) + enzalutamide (ENZA) versus placebo (PBO) + ENZA as first-line (1L) treatment in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC).

Authors

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Arun Azad

Peter MacCallum Cancer Centre, Melbourne, Australia

Arun Azad , Karim Fizazi , Nobuaki Matsubara , Peter C.C. Fong , Joan Carles , Neal D. Shore , Ugo De Giorgi , Robert J. Jones , Lawrence Ivan Karsh , Jae Young Joung , Andre P. Fay , Glenn Liu , Steven M. Yip , Stefanie Zschaebitz , Julia F. Hopkins , Nicola Di Santo , Xun Lin , Marielena Mata , Douglas Laird , Neeraj Agarwal

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Poster Details

Meeting

2023 ASCO Annual Meeting

Session Type

Poster Session

Session Title

Genitourinary Cancer—Prostate, Testicular, and Penile

Track

Genitourinary Cancer—Prostate, Testicular, and Penile

Sub Track

Prostate Cancer– Advanced/Castrate-Resistant

Clinical Trial Registration Number

NCT03395197

Citation

J Clin Oncol 41, 2023 (suppl 16; abstr 5056)

DOI

10.1200/JCO.2023.41.16_suppl.5056

Abstract #

5056

Poster Bd #

150

Abstract Disclosures