Sacubitril-valsartan improves longitudinal strain and ejection fraction in preclinical models treated with anthracyclines through NLRP3, MyD88 pathways resulting in a reduction of myocardial IL-1β, IL-6, TNF-α and growth factors.

Authors

null

Nicola Maurea

Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”-IRCCS, Naples, Division of Cardiology, Naples, Italy

Nicola Maurea , Martina Iovine , Simona Buccolo , Antonietta Caronna , Carlo Maurea , Annamaria Bonelli , Andrea Paccone , Irma Bisceglia , Maria Laura Canale , Vincenzo Quagliariello

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Poster Details

Meeting

2022 ASCO Annual Meeting

Session Type

Poster Session

Session Title

Symptoms and Survivorship

Track

Symptom Science and Palliative Care

Sub Track

Health Promotion/Behaviors

Citation

J Clin Oncol 40, 2022 (suppl 16; abstr 12063)

DOI

10.1200/JCO.2022.40.16_suppl.12063

Abstract #

12063

Poster Bd #

309

Abstract Disclosures

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