BRCA reversion mutations mediated by microhomology-mediated end joining (MMEJ) as a mechanism of resistance to PARP inhibitors in ovarian and breast cancer.

Authors

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Natalia Lukashchuk

AstraZeneca, Cambridge, United Kingdom

Natalia Lukashchuk , Joshua Armenia , Luis Tobalina , Thomas Hedley Carr , Tsveta Milenkova , Ying L Liu , Richard T. Penson , Mark E. Robson , Elizabeth Harrington

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Poster Details

Meeting

2022 ASCO Annual Meeting

Session Type

Poster Session

Session Title

Gynecologic Cancer

Track

Gynecologic Cancer

Sub Track

Ovarian Cancer

Clinical Trial Registration Number

NCT02983799, NCT02282020, NCT02000622

Citation

J Clin Oncol 40, 2022 (suppl 16; abstr 5559)

DOI

10.1200/JCO.2022.40.16_suppl.5559

Abstract #

5559

Poster Bd #

438

Abstract Disclosures

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