Background: To evaluate trends in postmenopausal breast cancer and mammogram utilization in Hispanic and White women in the United States. Methods: Data on postmenopausal breast cancer was obtained from the United States Cancer Statistics Public Use Database between 2001 and 2018. Rates of mammogram screening for women ages 18 and older were evaluated using the Behavioral Risk Factor Surveillance System (BRFSS) from 2000 and 2018. Obesity rates for women ages 18 and older were extracted from BRFSS between 2001 and 2016. SEER*Stat 8.3.8 and Joinpoint regression program 4.8.0.1 were used to calculate incidence trends. Breast cancer and obesity incidence and trends were described using average annual percent change (AAPC). Mammogram screening trends were described using average biennial percent change (ABPC). Age groups were divided into five-year or ten-year intervals. Results: Over the past eighteen years, early-stage breast cancer in Hispanic women has increased annually by 1.06% (p = 0.000) and advanced-stage has also increased annually by 0.81% (p = 0.000). In contrast, there was no increase in early-stage cancer in White women, however, advanced stage increased by 1.06% annually (p = 0.000). Compared to White woomen, Hispanic women are more likely to be unscreened with mammograms (18.17% vs. 40.06%). Over time, the unscreened population is decreasing at 3.43% for White women compared to only 1.24% in Hispanic women (p = 0.000, p = 0.001). Overall in the U.S., the never-screened population has decreased biennially by 2.88% (p = 0.000). In 2016, 33.16% of Hispanic women and 28.13% of White women were considered obese, and this obesity rate has been increasing at 2.6% and 2.4%, respectively (p = 0.000). Conclusions: Our data showed that early- and advanced-stage breast cancer has been increasing in Hispanic women in the United States. Hispanic women were also more likely to be obese and less likely to undergo screening compared to White women.