Association of a very high tumor mutational load with increased CD8+ and PD-1+ T-cell infiltration and improved clinical outcomes to PD-(L)1 blockade across different PD-L1 expression levels in non-small cell lung cancer.

Authors

null

Biagio Ricciuti

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA

Biagio Ricciuti , Kathryn Cecilia Arbour , Joao Victor Machado Alessi , Navin Mahadevan , James Lindsay , Rileen Sinha , Natalie I. Vokes , Gonzalo Recondo , Giuseppe Lamberti , Hira Rizvi , Giulia Costanza Leonardi , Andrew J. Plodkowski , Kristen Felt , Michael Tolstorukov , Pasi A. Janne , Eliezer Mendel Van Allen , Lynette M. Sholl , Scott J. Rodig , Matthew D. Hellmann , Mark M. Awad

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Poster Details

Meeting

2021 ASCO Annual Meeting

Session Type

Poster Discussion Session

Session Title

Lung Cancer—Non-Small Cell Metastatic

Track

Lung Cancer

Sub Track

Metastatic Non–Small Cell Lung Cancer

Citation

J Clin Oncol 39, 2021 (suppl 15; abstr 9018)

DOI

10.1200/JCO.2021.39.15_suppl.9018

Abstract #

9018

Abstract Disclosures

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