Effect of chronic neurogenic pain on blood levels of hormones in patients with melanoma depending on their gender.

Authors

null

Viktoria V. Pozdnyakova

Rostov Research Institute of Oncology, Rostov-on-Don, Russian Federation

Viktoria V. Pozdnyakova , Elena M. Frantsiyants , Valeria A. Bandovkina , Ludmila Ya. Rozenko , Maria G. Ilchenko , Elena I. Agarkova , Natalia A. Zakharova , Olga V. Khokhlova , Yuriy V. Przhedetskiy , Viktoria Yu. Przhedetskaya , Oleg I. Kit

Organizations

Rostov Research Institute of Oncology, Rostov-on-Don, Russian Federation

Research Funding

No funding received
None

Background: Chronic neurogenic pain (CNP) as a comorbid disease is quite frequent, but its effect on malignant diseases is poorly studied. The risk of cutaneous melanoma in women is higher, but the disease course in men is more severe. The purpose of the study was to reveal the effect of CNP on the levels of sex hormones in the blood of patients with melanoma depending on their gender. Methods: Blood levels of estradiol (E2), estrone (E1), progesterone (P4), testosterone (T) and prolactin (PRL) were measured by ELISA in patients with Т3-4NxM0 melanoma (M): 21 women with CNP (pelvic pain - 7, osteochondrosis – 14), mean age 67.2±2.7 years; 17 men with CNP (osteochondrosis), mean age 65.6±3.1 years. The control group included patients with melanoma similar in age, gender and disease stages without CNP. Results: In women with M+CNP, E2 and P4 were decreased by 1.8 times, while E1 was 1.4 times, T – 2 times, PRL – 1.5 times higher, compared to controls. In men with M+CNP, blood levels of estrogens were unchanged, PRL was 2.5 times lower and P4 and T – 1.3 times higher, compared to the corresponding control levels. Conclusions: CNP upregulated blood levels of androgens in both male and female melanoma patients, and caused the inversion of estrogens only in women with the prevalence of E1 over E2. Gender differences in the CNP influence included the elevation of progesterone and a decrease of prolactin in the blood of men, and P4 deficiency with increased prolactin in women with M+CNP. The specific effect of CNP on the hormonal profile in patients with cutaneous melanoma should be considered in choosing antitumor treatment.

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Abstract Details

Meeting

2020 ASCO Virtual Scientific Program

Session Type

Publication Only

Session Title

Publication Only: Melanoma/Skin Cancers

Track

Melanoma/Skin Cancers

Sub Track

Local-Regional Disease

Citation

J Clin Oncol 38: 2020 (suppl; abstr e22097)

DOI

10.1200/JCO.2020.38.15_suppl.e22097

Abstract #

e22097

Abstract Disclosures

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