Outcomes of elderly patients with resectable liver metastases from colorectal cancer (CRLM): Single center experience.

Authors

null

Laura Mansour

Université de Montréal, Montreal, QC, Canada

Laura Mansour , Rami Mohamad Nassabein , Filip Gryspeerdt , Franck Vandenbroucke-Menu , Francine Aubin , Jean-Pierre M. Ayoub , Michel Dagenais , Real W. Lapointe , Richard Letourneau , Marylene Plasse , Andre Roy , Simon Turcotte , Mustapha Tehfe

Organizations

Université de Montréal, Montreal, QC, Canada, Centre Hospitalier de L'université de Montréal (CHUM-Notre Dame, Montreal, QC, Canada, Centre Hospitalier d'Université de Montreal, Montreal, QC, Canada, Hepato-Pancreato-Biliary Surgery Service, Centre Hospitalier De L'université De Montréal (CHUM), Montréal, QC, Canada, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada, CHUM Hopital St Luc, St Lambert, QC, Canada, Hepato-Pancreato-Biliary Surgery Service and Research Centre, Centre Hospitalier De L'université De Montréal (CHUM), Montréal, QC, Canada, Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, QC, Canada

Research Funding

No funding received
None

Background: Half of patients with colorectal cancer develop liver metastases during the course of their disease. Surgery is the only potentially curative option for CRLM if resectable. Treatment of patients over 70 years old is challenging mainly because of comorbidities and other geriatric syndromes. Thus, we intended to report our experience with elderly patients with resectable CRLM. Methods: After approval by the Institutional Review Board (IRB), all records from a prospectively collected database at Centre Hospitalier de l’Université de Monréal (CHUM) were retrospectively analyzed. Clinicopathological characteristics, surgery and chemotherapy treatment modalities were reviewed. RFS and OS in patients ≥ 70y were calculated using the Kaplan Meier survival curve. Results: From 2010 to 2016, 101 patients older than 70 years were identified. Safety and surgical complications were previously reported. Median age was 75 years. CRLM were synchronous in 46.5% and metachronous in 53.5%. Relapse free survival (RFS) of patients ≥ 70 years was 33.7 months. Overall survival (OS) of patients ≥70 years was comparable to those of less than 65 years old (median OS: 56 vs 62 months; p = 0.15, respectively). Hepatic relapse showed worse survival when compared to extra-liver recurrence, mOS: 44 vs 33.2 vs 29.3 months for non-hepatic, hepatic only and hepatic with other sites respectively (trend p = 0.034). Although non-statistically significant, Patients with metachronous CRLM had superior mOS compared to those with synchronous disease (58.7 vs 44.7 months; p = 0.22). Conclusions: Survival Outcomes of patients with an age ≥ 70 years were comparable to those of younger patients and what is reported in literature. Age should not be a limiting factor in the management of elderly patients with resectable CRLM. Hepatic metastatectomies +/- chemotherapy should be offered with curative intents.

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Abstract Details

Meeting

2020 Gastrointestinal Cancers Symposium

Session Type

Poster Session

Session Title

Poster Session C: Anal and Colorectal Cancer

Track

Colorectal Cancer,Anal Cancer

Sub Track

Patient-Reported Outcomes and Real-World Evidence

Citation

J Clin Oncol 38, 2020 (suppl 4; abstr 34)

Abstract #

34

Poster Bd #

B6

Abstract Disclosures

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