Trends of survival based on race and ethnicity in gastrointestinal tract neuroendocrine tumor.

Authors

null

Suleyman Yasin Goksu

The University of Texas Southwestern Medical Center, Dallas, TX

Suleyman Yasin Goksu , Muhammad Shaalan Beg , Nina Niu Sanford , Benjamin David Fangman , Sarah Herrman , Busra Bacik Goksu , Aravind Sanjeevaiah , Amy Little Jones , Radhika Kainthla , Syed Mohammad Ali Kazmi , Udit Verma

Organizations

The University of Texas Southwestern Medical Center, Dallas, TX, The University of Texas Southwestern, Dallas, TX, UT Southwestern Medical Center, Dallas, TX, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Funding

No funding received
None

Background: There is paucity of data about racial/ethnic disparities in gastrointestinal tract neuroendocrine tumors (GiNET). We aimed to study the race/ethnic differences in disease characteristics and survival in GiNET. Methods: We analyzed the SEER database to identify cases with non-pancreatic GiNET between 2004 and 2015. We evaluated trends in incidence and outcomes between Hispanic, non-Hispanic/non-Black (NH/NB) and non-Hispanic Black (NHB). Kaplan-Meier method and cox regression model were performed for overall survival (OS) after adjusting for stage, grade, gender, race/ethnicity, and surgery. Results: 25,826 cases were included, 12.7% were Hispanic, 18.5% NHB and 68.8% NH/NB; males comprised 46.8%, 50.5%, 41.9%, respectively (p < 0.001). The overall incidence of GiNET increased two-folds in the ten years. The highest increase in incidence was observed in appendiceal NET followed by small intestine NET, and this increase was observed mostly among Hispanic population. NH/NB cases were older ( > 65 years) (31.3% vs. 23.3% vs. 23.5%; p < 0.001) and presented with metastatic disease (17.8% vs. 12.7%, 12.0%; p < 0.001). On multivariate analysis Hispanic population had significantly better OS than NH/NB and NHB (HR: 1.25 95% CI: 1.14-1.37 and HR: 1.15 95% CI: 1.033-1.28, respectively). For stage-4 low- and intermediate-grade GiNET, OS was better if surgery was performed (p < 0.001), and this trend was most pronounced among Hispanic as compared to NH/NB (HR 1.35, 95% CI 1.07-7.71). Conclusions: The incidence of GiNET had increased two-fold in the last ten years with the highest increase in Hispanic. However, Hispanic had significantly better overall survival than NH/NB and NHB population.

Hispanic (%)Non-Hispanic Non-Black (%)Non-Hispanic Black (%)p-value
Appendix212 (6.5)1,316 (7.4)141 (3)< 0.001
Esophagus/Stomach646 (19.7)2,227 (12.5)439 (9.2)
Small Intestine733 (22.4)6,376 (35.9)1,449 (30.4)
Large Intestine1,688 (51.5)7,858 (44.2)2,741 (57.5)
2004-2006530 (16.2)3,488 (19.6)796 (16.7)< 0.001
2007-2009693 (21.1)4,042 (22.7)1,096 (23)
2010-2012856 (26.1)4,597 (25.9)1,314 (27.5)
2013-20151,200 (36.6)5,650 (31.8)1,564 (32.8)

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Abstract Details

Meeting

2020 Gastrointestinal Cancers Symposium

Session Type

Poster Session

Session Title

Poster Session B: Hepatobiliary Cancer, Neuroendocrine/Carcinoid, Pancreatic Cancer, and Small Bowel Cancer

Track

Hepatobiliary Cancer,Neuroendocrine/Carcinoid,Pancreatic Cancer,Small Bowel Cancer,Other GI Cancer

Sub Track

Patient-Reported Outcomes and Real-World Evidence

Citation

J Clin Oncol 38, 2020 (suppl 4; abstr 607)

Abstract #

607

Poster Bd #

F10

Abstract Disclosures

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