Background: Intractable pain is one of the invincible entities in cancer and about 75% of cancer patients require inpatient hospital admission at least once in their treatment course. Palliative care service has a significant role in managing cancer pain and thus reducing the recurrent hospital admissions. Methods: We analyzed the association of Mortality Rate (MR) with age, sex, race, emergency admission, hospital regions among patients admitted for Neoplasm Related Pain (NRP). Data from the National Inpatient Sample (NIS) database for the year 2016 was reviewed. Patients admitted with a principal diagnosis of NRP were identified using ICD-10 code. The prevalence of each cancer and characteristics of admissions were also studied. Statistical analysis was performed using STATA and the association was depicted with Chi-Square test. Results: A total of 28609 admissions with a primary diagnosis of NRP was identified. The mean age of admission was found to be 59.38 ± 0.08, with 53.19% patients ≥ 60 years of age. 51.39% were females, 65.58% were Caucasians,16.25% were African Americans. The overall inpatient hospital MR for NRP was 8.16%. There was a significant difference in the MR between inpatients ≥ 60 years of age and <60 years (MR=9% in age ≥ 60, P<0.001). MR was high among Caucasians (8.31%, P=0.021). There exists a small difference in the MR among hospital regions (highest in West at 8.36%, lowest in South 7.68%, p=0.001). There was no statistically significant difference in the MR among sex, emergency vs elective admissions. NRP was most commonly associated with secondary neoplasms, the prevalence in the order: secondary malignant neoplasm of bone (38%), liver and bile duct (26%), followed by lung (11%), peritoneum (10%), brain (9%). The encounter for palliative care was documented only in 8530 admissions (29%). Conclusions: MR is high on people with NRP who are ≥ 60 years, Caucasians. Regional difference also plays a role in this. Further studies are needed to address the causes of the difference. Utilization of palliative care service is found to be less in NRP admissions. Future admissions and mortality rates can be reduced by the effective utilization of palliative care, optimization of outpatient pain management.