Real-world bevacizumab utilization and outcomes in first-line ovarian cancer.

Authors

null

Matthew J. Monberg

Merck & Co., Inc., Kenilworth, NJ

Matthew J. Monberg , Jennifer P Hall , Rebecca Moon , Olivia Higson , Kimmie McLaurin , Tapashi Dalvi

Organizations

Merck & Co., Inc., Kenilworth, NJ, Adelphi Real World, Manchester, United Kingdom, AstraZeneca Pharmaceuticals, LP, Gaithersburg, MD

Research Funding

Pharmaceutical/Biotech Company

Background: Bevacizumab (B) is approved in combination with carboplatin and paclitaxel, followed by B monotherapy, for the treatment of advanced ovarian cancer (OC) following surgery. We sought to describe B utilization and outcomes of B in first-line (1L) OC within the US and EU. Methods: This cross-sectional study included patients who were actively receiving treatment for OC. Data were collected at a single time point from 2496 patient forms between December 2017 and March 2018 from 340 oncologists/ gynecologists across the US, France, Germany, Italy, Spain, and the UK. Patients were platinum sensitive if progression was noted > 6 months after frontline platinum therapy and resistant if the interval was 0-6 months. This analysis included patients who received 1L chemotherapy (chemo) with no maintenance or 1L chemo with bevacizumab maintenance. Results: B was used in combination with chemo at 1L and as 1L maintenance monotherapy in 11% total study patients. Those receiving 1L + B were more likely to have Stage IV disease, have good performance status (PS) at diagnosis, and receive BRCA testing than patients receiving chemo only. Treatment response, platinum sensitivity, and activities of daily living are shown in the Table. Results did not vary by BRCA status. Conclusions: This study highlights differences in patient characteristics and outcomes between patients receiving/ who received 1L chemo only and those receiving/ who received B, however, this study was not designed to formally compare 1L treatment options.

Total1L Chemo Only Treatment + No 1L maintenance
1L Chemo + B + B Maintenance
N who initiated 1L14981232266
Mean age, yrs646461
Stage IV, %656376
ECOG PS 0-1 at diagnosis, %817892
BRCA tested, %524771
BRCA positive of those screened, %242522
Some decrease in activities of daily living, %737371
N who completed 1L945742203
Complete response, partial response or stable disease at completion of 1L, %837996
Platinum sensitive, %403558
Platinum resistant, %141315
Platinum refractory, %14174
Received 2L platinum, %615872
Received 2L nonplatinum, %394228
Mean 1L completed treatment duration, months (N)4.9 (634)5.1 (434)4.4 (200)
Mean 1L completed maintenance duration, months (N)8.3 (149)NA (NA)8.3 (149)
Mean time off treatment between 1-2 years of diagnosis, months (N)6.3 (221)8.4 (142)2.7 (79)

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Abstract Details

Meeting

2019 ASCO Annual Meeting

Session Type

Poster Session

Session Title

Gynecologic Cancer

Track

Gynecologic Cancer

Sub Track

Ovarian Cancer

Citation

J Clin Oncol 37, 2019 (suppl; abstr 5578)

DOI

10.1200/JCO.2019.37.15_suppl.5578

Abstract #

5578

Poster Bd #

401

Abstract Disclosures