Body weight changes in young breast cancer survivors and associated predictors.

Authors

null

Tal Sella

Dana Farber Cancer Institute, Boston, MA

Tal Sella , Zhenying Tan-Wasielewski , Shoshana M. Rosenberg , Philip Daniel Poorvu , Kathryn Jean Ruddy , Shari I. Gelber , Rulla M. Tamimi , Lidia Schapira , Steven E. Come , Jeffrey M. Peppercorn , Virginia F. Borges , Ann H. Partridge , Jennifer A. Ligibel

Organizations

Dana Farber Cancer Institute, Boston, MA, Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, Dana-Farber Cancer Institute, Boston, MA, Mayo Clinic, Department of Oncology, Rochester, MN, Brigham and Women's Hospital, Boston, MA, Stanford Cancer Center, Palo Alto, CA, Beth Israel Deaconess Medical Center, Boston, MA, Massachusetts General Hospital, Boston, MA, University of Colorado Comprehensive Cancer Center, Aurora, CO

Research Funding

Other Foundation

Background: Weight gain after cancer diagnosis is common in cancer survivors and has been linked to increased treatment toxicity, poor quality of life, and increased risk of second cancers and overall mortality. Young breast cancer (BC) survivors may be especially susceptible to weight changes given the impact of treatments such as chemotherapy and hormonal therapy on menopausal status. Methods: We identified women with Stage 0-III breast cancer diagnosed at ≤40 years (y) between 2006-2016 from a multi-center prospective cohort study. Clinical data including self-reported pre-diagnosis and follow-up weights were obtained using baseline and follow-up patient surveys. Participants missing baseline weight, pregnant at diagnosis/within 1y of diagnosis or with BC recurrence within 1y were excluded; those pregnant or with BC recurrence between 1-3y from diagnosis were excluded from the 3y analysis. Menopausal status at baseline and treatment-related amenorrhea (TRA) in follow-up were defined by self-reported last menstrual period. Factors associated with weight gain (>5%) were evaluated using univariate two-sided Fisher's exact test. Results: At baseline, 1y and 3y post diagnosis, 956, 899 and 687 women were eligible for analysis respectively. Median age at diagnosis was 37y (17 - 40), 65% received endocrine therapy and 74% chemotherapy. Premenopausal status was verified in 94% at baseline. Mean BMI at baseline was 24.4 (SD 5.3) kg/m2; 20% (187/956) were overweight and 12% (116/956) obese. At 1y and 3y, mean BMI increased modestly to 24.7 (SD 5.6) and 24.9 (SD 5.2), respectively with weight gain (>5%) observed in 18% (164/899) and 13% (87/687) respectively. 37% (300/804) and 32% (196/615) of eligible premenopausal subjects experienced TRA at 1y and 3y, respectively. Receipt of chemotherapy, receipt of endocrine therapy and TRA were not associated with weight gain at any timepoint. Conclusions: In this large prospective cohort of young BC survivors, mean BMI increased only modestly over time. Self-reported weight gain was not associated with treatment and not exacerbated by TRA. Further analysis to understand the effects of physical activity and other predictors of weight gain in this population are ongoing.

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Abstract Details

Meeting

2019 ASCO Annual Meeting

Session Type

Poster Session

Session Title

Symptoms and Survivorship

Track

Symptom Science and Palliative Care

Sub Track

Late and Long-Term Adverse Effects

Citation

J Clin Oncol 37, 2019 (suppl; abstr 11574)

DOI

10.1200/JCO.2019.37.15_suppl.11574

Abstract #

11574

Poster Bd #

266

Abstract Disclosures

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