Survival of patients with cervical cancer and diabetes: An exploratory study.

Authors

null

Maria Luisa Romero

Universidad Autónoma de Nuevo León, Monterrey, Mexico

Maria Luisa Romero , Jose Luis Gonzalez Vela , David Hernandez Barajas , Ascary Velazquez-Pacheco , Abrham Josafath Hernández , Irma Anaid Villarreal Ondarza , Roberto Alejandro Escobedo Rodriguez , Oscar Vidal-Gutiérrez

Organizations

Universidad Autónoma de Nuevo León, Monterrey, Mexico, UANL, Monterrey, NL, Mexico, University Cancer Centre , Monterrey, Mexico, Centro Universitario contra el Cancer, Monterrey, Mexico, Universidad Autonoma de Nuevo Leon, Monterrey, NL, Mexico

Research Funding

Other

Background: Mexico is the sixth country with the highest number of diabetics, this being the second cause of death. Between 8-18% of cancer patients have Diabetes (DM) as comorbidity. Studies have reported DM has worst prognosis in Overall Survival (OS) and Progression Free Survival (PFS) in patients with Cervical Cancer (CC). Aim: to compare OS in patients (pt) with a diagnosis of CC and DM, and to evaluate this outcome in relation to the clinical stage and the glycemic level at diagnosis of CC. Methods: data was obtained from pt treated for invasive CC between 2006 and 2016. Pt aged ≥20 years, with squamous, adenocarcinoma or adenosquamous histology. 59 pt with CC and DM in group 1 (G1), and 118 pt with CC without DM in group 2 (G2), paired 1:2 according to clinical stage, age and comorbidities. Results: Prevalence of DM in pt with CC was 16%. Follow-up of 142.2 months (median of 40.4 months), lower OS for G1 was seen (74.6% vs 77.1%), without statistical significance (p.803). PFS was similar for both groups (67.8% G1 vs 66.9% G2, p .608). In patients with locally advanced and metastatic disease, a lower OS and PFS were found in G1, without statistical significance. 42.4% diabetic pt had glycemic level < 130 mg / dL). OS was lower in pt with higher glycemic level (70.6% vs 80%), not being statistically significant (p .32). PFS was similar in both groups (G1: 68% vs G2: 67.6%, p.852). Analysis for influence of metformin treatment, evidenced a higher OS among pt receiving metformin (84.8% vs 61.5%), without statistical significance (p 0.65). PFS was higher in the metformin group (78.8 vs 53.8%), with a trend towards statistical significance (p .052). Conclusions: Pt diagnosed with CC and DM do not have different OS compared to those without DM. There was a tendency towards the improvement of PFS in pt with CC and DM, who received metformin.

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Abstract Details

Meeting

2019 ASCO Annual Meeting

Session Type

Publication Only

Session Title

Gynecologic Cancer: Publication Only

Track

Gynecologic Cancer

Sub Track

Cervical Cancer

Citation

J Clin Oncol 37, 2019 (suppl; abstr e17008)

DOI

10.1200/JCO.2019.37.15_suppl.e17008

Abstract #

e17008

Abstract Disclosures

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