Background: The Michigan Oncology Quality Consortium (MOQC) is a statewide collaborative quality initiative (CQI) sponsored by Blue Cross/Blue Shield of Michigan. The consortium uses Quality Oncology Practice Initiative (QOPI) measures to identify gaps in care and opportunities to improve quality. Data are collected on patients regardless of payer. MOQC includes nearly 90% of eligible medical oncologists (n = 364) in Michigan. We describe physician engagement within MOQC and quality improvement efforts after implementation of a regional structure in the CQI. Methods: The MOQC regional structure was introduced in Spring 2017. Forty-eight practices self-selected into 6 regions roughly by geographic location. Beginning in Spring 2017, a physician from each practice was required to attend both the Spring and Fall Regional Meetings and encouraged to bring an additional representative (e.g. administrative leader) from their practice. Regional meetings were facilitated by the MOQC Coordinating Center. Within each region, practices selected to work on one measure from a finite set of QOPI measures. and shared best practices gleaned from their quality improvement work, according to the Plan-Do-Study-Act cycle of quality improvement. We report on our primary outcome, the change in physician engagement, defined as attendance at biannual MOQC meetings (distinct from the Regional Meetings), before and after the introduction of the regional structure. Results: Provider engagement, measured by attendance at the biannual meetings increased from an average of 17.3 physicians in the 3 years before the introduction of the regional structure, to 33 physicians in the first meeting, and 22 physicians in the second meeting after the introduction of the regional structure. Conclusions: Implementation of a regional structure increased provider engagement, and provided a systematic approach to the launching of quality improvement efforts in an oncology CQI. Engaging providers at the regional level, which incorporates cultural aspects of geographically similar practices, may provide opportunities not otherwise recognized in larger consortia.