McKesson Specialty Health, The Woodlands, TX
Elizabeth Anne Johnson, Jay C. Andersen, Sandy Smith, Bharat Patel, Susan S. Night, Lauren Steckel
Background: As an innovative industry leader of Research Site Management Organizations, US Oncology Research (USOR) sought to develop a best practice to support over 65 community practice network sites to comply with Sponsor data entry expectations. Efforts led by the Clinical Trial Manager (CTM) focused on bringing research site awareness to priority data, Sponsor deadlines, and weekly performance feedback via the ‘Healthy Data Habits Pathway’. Methods: The Healthy Data Habits Pathway was created to define the role of CTM involvement in data management operations on behalf of USOR. In collaboration with Sponsor, the USOR CTM reviewed data management reports weekly for data entry trends. Results: Two separate oncology clinical trials (different Sponsors) implemented the Pathway with renal and breast oncology indications. The renal trial demonstrated an almost 90% reduction in total query count for 8 sites in 7 months while the breast trial reported 7 of 14 sites (50%) meeting Sponsor goal of 20 or fewer total queries in 13 weeks. Interventions included emailed notifications, site manager calls, and weekly CTM-Sponsor collaboration teleconferences. Conclusions: Clinical research Sponsors and sites both strive towards maintaining data integrity in an ever-evolving atmosphere of complex oncology trials and increasingly-detailed data capture requirements. Implementation of Pathway interventions increases site and Sponsor engagement in daily data management operations.
Healthy Data Habits Pathway | |
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Develop A Plan | Obtain information regarding proposed Sponsor data management plan and expectations |
Identify Trends | Collaborate with the Sponsor study team to identify trends in query resolution and data entry timeliness |
Monitor Progress | Encourage open discussion during study team meetings as to site progress |
Alert Early and Often | Establish predictive communication conduits with sites and Sponsor |
Communicate Timelines | Communicate timelines and subsequent expectations for data entry. Obtain site feedback in their ability to meet data deadlines and assist as appropriate. Host a Sponsor post-conference to review and critique data management plan effectiveness. |
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Abstract Disclosures
2018 ASCO Quality Care Symposium
First Author: Susan S. Night
2023 ASCO Quality Care Symposium
First Author: Ying Wang
2019 ASCO Quality Care Symposium
First Author: David Michael Waterhouse
2023 ASCO Annual Meeting
First Author: Heather McKee Hurwitz