Indiana University Department of Radiation Oncology, Indianapolis, IN
Feng-Ming Spring Kong , Chunyu He , Yong Zang , Sandra K. Althouse , Lautenschlaeger Tim , Kenneth Kesler
Background: There are several matched-paired analysis reports of comparing the long-term outcome between Stereotactic Body Radiation Therapy (SBRT) and surgical resection. Most of them are small series. This study aimed to compare the long-term overall survival (OS) after SBRT and surgery from a single medical center with surgery performed with the same group of surgeons. Methods: We used our cancer registry of 2005-2015. Patients with clinical staged T1 and T2 N0 diseases treated with either primary surgery or SBRT . Only patients elder than 65 years. The log rank p-value was used for overall survival comparison between the groups. Cox regression was used for univariate test for age, gender, race, smoking history, alcohol use, primary site location, laterality, T stage, and histology grade. Variables with p < 0.05 from univariate analysis were then used for propensity score based matching to compare the effect of surgery or SBRT on overall survival. Results: A total 1244 patients with clinically staged T1-T2 N0 NSCLC, 774 patients were elder than 65 years and matched: 508 patients with surgery and 266 patients with SBRT. The median age was 73 years (range: 65-96 years), 50% were male, and 67% had T1 disease. Median follow-up was 60 months.Age (p < 0.001), gender (p = 0.007), primary lobar location, middle and lower lobe (p < 0.001), grade of 1, 2, 3, and 4 (p< 0.001) and treatment modality of surgery versus SBRT (P < 0.001) were all significantly associated with OS under univariate analysis. The median OS and survival rates at one-, three- and five years were 81 months (95%CI:66-92), 85%, 70% and 58% after surgery, and 37 months (95%CI:28-46), 83%, 50% and 29% after SBRT, respectively (log-rank p< 0.001). Conclusions: This matched analysis, representing the largest one in the literature, demonstrated that patients treated with surgery have significantly better long-term survival than that of SBRT in elderly patients. This result varies from some of previous reports showing similar survival between SBRT and surgery. Prospective randomized study is needed to determine whether SBRT can present as an alternative for operable patients.
Disclaimer
This material on this page is ©2024 American Society of Clinical Oncology, all rights reserved. Licensing available upon request. For more information, please contact licensing@asco.org
Abstract Disclosures
2019 ASCO Annual Meeting
First Author: Michael Kharouta
2019 Breakthrough
First Author: Hirsh Koyi Sr.
2021 ASCO Annual Meeting
First Author: Swapna Narayana
2023 ASCO Annual Meeting
First Author: Gustavo Schvartsman