Long-term survival comparison of stereotactic radiotherapy versus surgery for elderly patients with clinical stage T1-T2 non-small cell lung cancer.

Authors

Feng-Ming Kong

Feng-Ming Spring Kong

Indiana University Department of Radiation Oncology, Indianapolis, IN

Feng-Ming Spring Kong , Chunyu He , Yong Zang , Lautenschlaeger Tim , Kenneth Kesler , Sandra K. Althouse

Organizations

Indiana University Department of Radiation Oncology, Indianapolis, IN, Indiana University Department of Radiation Oncology, Department of Thoracic Radiation Oncology, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China, Indiana University Department of Biostatistics, Indianapolis, IN, Department of Radiation Oncology, Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, Indiana University, Indianapolis, IN, Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN

Research Funding

NIH

Background: There are several matched-paired analysis reports of comparing the long-term outcome between Stereotactic Body Radiation Therapy (SBRT) and surgical resection. Most of them are small series. This study aimed to compare the long-term overall survival (OS) after SBRT and surgery from a single medical center with surgery performed with the same group of surgeons. Methods: We used our cancer registry of 2005-2015. Patients with clinical staged T1 and T2 N0 diseases treated with either primary surgery or SBRT . Only patients elder than 65 years. The log rank p-value was used for overall survival comparison between the groups. Cox regression was used for univariate test for age, gender, race, smoking history, alcohol use, primary site location, laterality, T stage, and histology grade. Variables with p < 0.05 from univariate analysis were then used for propensity score based matching to compare the effect of surgery or SBRT on overall survival. Results: A total 1244 patients with clinically staged T1-T2 N0 NSCLC, 774 patients were elder than 65 years and matched: 508 patients with surgery and 266 patients with SBRT. The median age was 73 years (range: 65-96 years), 50% were male, and 67% had T1 disease. Median follow-up was 60 months.Age (p < 0.001), gender (p = 0.007), primary lobar location, middle and lower lobe (p < 0.001), grade of 1, 2, 3, and 4 (p< 0.001) and treatment modality of surgery versus SBRT (P < 0.001) were all significantly associated with OS under univariate analysis. The median OS and survival rates at one-, three- and five years were 81 months (95%CI:66-92), 85%, 70% and 58% after surgery, and 37 months (95%CI:28-46), 83%, 50% and 29% after SBRT, respectively (log-rank p< 0.001). Conclusions: This matched analysis, representing the largest one in the literature, demonstrated that patients treated with surgery have significantly better long-term survival than that of SBRT in elderly patients. This result varies from some of previous reports showing similar survival between SBRT and surgery. Prospective randomized study is needed to determine whether SBRT can present as an alternative for operable patients.

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Abstract Details

Meeting

2018 ASCO Annual Meeting

Session Type

Poster Discussion Session

Session Title

Lung Cancer—Non-Small Cell Local-Regional/Small Cell/Other Thoracic Cancers

Track

Lung Cancer

Sub Track

Local-Regional Non–Small Cell Lung Cancer

Citation

J Clin Oncol 36, 2018 (suppl; abstr 8511)

DOI

10.1200/JCO.2018.36.15_suppl.8511

Abstract #

8511

Poster Bd #

117

Abstract Disclosures

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