Background: An increasing proportion of cancer surgeries are ambulatory (≤ 1 day in hospital) procedures. Providing patients and their caregivers with ongoing, real-time support after discharge is imperative to delivering high-quality postoperative care in this new health care environment. Despite abundant evidence that patient self-reporting of symptoms improves quality of care, Reference: 1. Kotronoulas G, Kearney N, Maguire R, et al. What is the value of the routine use of patient-reported outcome measures toward improvement of patient outcomes, processes of care, and health service outcomes in cancer care? A systematic review of controlled trials. Journal of Clinical Oncology. 2014;32(14):1480-1501. the most effective way to monitor and manage such data remains unknown. Methods: This is a two-armed, prospective randomized controlled trial evaluating two approaches to the management of patient-reported data: (1) Team Monitoring—symptom monitoring by the clinical team, with nursing outreach if symptoms exceed normal limits; and (2) Enhanced Feedback—real-time feedback to patients about expected symptom severity, with patient-activated care as needed. It is hypothesized that Enhanced Feedback about expected symptom severity would be more effective than Team Monitoring in improving patient-centered outcomes and the patient/caregiver experience. Breast, prostate, gynecologic, and head and neck cancer patients undergoing ambulatory cancer surgery (n = 1,700) will complete an electronic survey about their symptoms for up to 30 days after surgery. Information provided to patients in the Enhanced Feedback group is procedure-specific and based on continuously updated survey data from previous patients. Qualitative interviews will also be performed. Accrual began in August 2017. Primary outcomes will evaluate unplanned emergency department visits within 30 days. Secondary outcomes will assess the patient/caregiver experience (i.e., patient engagement, patient anxiety, and caregiver burden). Findings will be relevant in designing future coordinated care models targeting improved health care quality and patient experience. Clinical trial information: NCT03178045