Michigan State University, East Lansing, MI
Lilit Karapetyan , Ling Wang , Joseph Gardiner , Heather Laird-Fick
Background: Studies have demonstrated inconsistent differences in the epidemiology and outcomes for gastric cancer (GC) based on race, ethnicity, and gender. We examined the association between these factors and diagnoses of GC in a cohort of patients in Michigan. Methods: We reviewed patients with GC diagnosed between 1990 and 2014 and enrolled in the Michigan Cancer Surveillance Program. Patients were followed up through 2016. Data extracted were age and stage at diagnosis, gender, race, and survival status at last follow-up. Statistical comparisons were assessed by chi-square tests in contingency tables and by the log-rank test for survival. Results: We identified 11,105 patients (66.5% male, 75.6% non-Hispanic White, 16.7% non-Hispanic black, 2.0% Hispanic, 1.5% Asian/Pacific Islanders, 3.9% other race) with complete data for analysis. Median age at time of diagnosis was 72 years (range 15 to 106 years). Males were diagnosed at younger age than females (median age: males = 70, females = 75, p < .0001). The distribution tumor stage was I (21.9%), II (30.2%), III (29.9%), IV (17.3%) and un-staged ( < 1%), and differed by sex (p < .003). Race was associated with stage (p = 0.036). There was a significant association of stage with survival (p < .0001), Stage I with the longest median survival.There was a significant association of race with survival (p < .018). Median survival time was lowest among non-Hispanic Black followed by non-Hispanic White, Asian/PI, Hispanic, Other race. There was a no significant association of sex with survival. Conclusions: Race, age at diagnosis and stage at diagnosis were associated with survival, but not sex. Future analyses will explore the effects of treatment modalities on survival.
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Abstract Disclosures
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