A phase 1a / 1b first-in-human, open-label, dose-escalation, safety, pharmacokinetic, and pharmacodynamic study of oral TP‑0903, a potent inhibitor of AXL kinase, administered daily for 21 days to patients with advanced solid tumors.

Authors

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John Sarantopoulos

Institute for Drug Development, Mays Cancer Center at University of Texas Health San Antonio, San Antonio, TX

John Sarantopoulos , Muhammad Shaalan Beg , Georgios Fotopoulos , Josephine Amalia Taverna , Stephen P. Anthony , Steven D. Weitman , Steven L Warner , Lars Mouritsen , David Bearss , Susan Smith , Holly Beever , Vivek Khemka

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Poster Details

Meeting

2018 ASCO Annual Meeting

Session Type

Poster Session

Session Title

Developmental Therapeutics—Clinical Pharmacology and Experimental Therapeutics

Track

Developmental Therapeutics and Translational Research

Sub Track

Other Novel Agents

Clinical Trial Registration Number

NCT02729298

Citation

J Clin Oncol 36, 2018 (suppl; abstr TPS2612)

DOI

10.1200/JCO.2018.36.15_suppl.TPS2612

Abstract #

TPS2612

Poster Bd #

430a

Abstract Disclosures

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