Background: There are few studies documenting the prevalence of malignancies and associated chronic conditions in free clinics. Cancer patients become lost to follow-up after treatment and end up in free clinics for further management of chronic morbidities. Charlson Comorbidity Index (CCI) has been used to study the mortality risk of patients with comorbid conditions, with the intention of adding standardized, weighted value to the disease profile of cancer patients. Methods: Demographic data and chronic disease measures were extracted from medical charts of patients managed in eight free clinics between January to December 2016 in the Tampa Bay Area. Descriptive statistics as well as Pearson correlation coefficient were used to demonstrate relationships between socioeconomic factors, cancer diagnoses, and comorbidities. CCI was used to assess severity of disease and mortality risk. Results: In 2016, 4804 uninsured patients were evaluated. From manual chart review, 86 patients (1.7%) were diagnosed with cancer. They were predominantly female (65.1%) and had an average age of 54.37 years (SD 13.42), significantly greater than patients without cancer (p < 0.001). Most common malignancies included breast (19, 22.09%), prostate (8, 9.30%), melanoma (6, 6.97%), cervical (5, 5.81%), colon (5, 5.81%), squamous carcinoma (5, 5.81%), ovarian (4, 4.65%), and lung cancer (4, 4.65%). The average length of survival was approximately 8.53 years (SD 7.55). Overall, cancer patients had a higher CCI (3.04 (1.928)), compared to patients without cancer (.90 (1.209)), p < 0.001. Cancer patients had more CCI comorbidities compared to patients without cancer (p < 0.001). Other factors of chronic disease including obesity and substance abuse are reported as correlations with cancer history among the uninsured. Conclusions: Uninsured patients from free clinics are considered outside the health care system and represent a unique population that is understudied in the literature. The most common malignancies identified in free clinics correlate with national epidemiology. Cancer patients without insurance have greater burdens of diseases as evidenced by their calculated CCI compared to uninsured patients without cancer.