Background: Despite data demonstrating an advantage of enoxaparin (LMWH) over heparin (UFH) for venous thromboembolism (VTE), an analysis of hospital prescribing trends showed use of each was about equal. In an attempt to increase LMWH over UFH use where it is not medically contraindicated, changes to the electronic medical record (EMR) for medical service patients and prescriber education was provided via multidisciplinary grand rounds conference in November 2016. This provided a unique opportunity to study trends in prescribing LMWH and UFH at our institution before and after aforementioned interventions. Methods: Patients were identified by Citrix Pharmacy. Data was extracted three months prior and after intervention (August 2016 to February 2017) excluding November 2016 when changes were made. Inclusion criteria were > 18 years of age and initiated on LMWH or UFH for VTE prophylaxis during hospitalization. Exclusion criteria were one time or duplicate orders and VTE treatment doses. The primary endpoint was to evaluate LMWH and UFH use among hospital services with focus in medical service which had both interventions compared to single intervention (grand rounds) among all other services. Results: 8921 patients were included in this study (4831 LMWH, 4090 UFH). In terms of utilization among all services prior to and after intervention for LMWH increased 51% to 57% and UFH decreased 49% to 43% respectively. Data was further divided into separate services (gynecology, medicine, neurology, obstetrics, orthopedics, surgery, thoracic and urology). Medicine comprised of 61% of patients and LMWH use was 52% to 60% and UFH was 48% to 40% respectively. Intervention with electronic order set and education with grand rounds for medicine patients resulted in 8% increase of LMWH use compared to all services 6%. Conclusions: Education through multidisciplinary grand rounds as well as changing the electronic order set to encourage LMWH as agent of choice over UFH for VTE prophylaxis in the medicine admission order set led to an increase in prescribing of LMWH in the medical services as well as all hospital services.