Risk evaluation about genetic screening among ovary cancer with regard to Lynch syndrome.

Authors

Min Kyu Kim

Min Kyu Kim

Sungkyunkwan University of Medicine, Samsung Chagngwon Hospital, Changwon, South Korea

Organizations

Sungkyunkwan University of Medicine, Samsung Chagngwon Hospital, Changwon, South Korea

Research Funding

Other

Background: Hereditary cancer syndrome about ovary cancer is mostly BRCA related. But mismatch repair genes related Lynch syndrome is also associated with it.There is not much study about risk evaluation about this among Korean population. We investigate this. Methods: A retrospective review of ovary cancer patients who was counseled about Lynch syndrome in Department of Obstetrics and gynecology, Samsung Changwon Hospital by single surgeon was done. Clinical information was extracted from the medical record including age, family and personal history of cancer, immunohistochemistry (IHC) of MLH1/MSH2, microsatellite instability test (MSI). Results: Total test was 26.mean age was 54(16~75) and fifty percent was serous type (13/26).There were 2 patients with Lynch syndrome related cancer family history (stomach and ovary) among their 1st degree relatives. Only one patient has abnormal MLH1 IHC.There were three unstable MSI patients (BAT26, D2S123, D55346, and NR21). Conclusions: We found three abnormal MSI patients among this population. Cost effective algorithm using multiple genetic testing to find Lynch syndrome associated ovary cancer patients should be developed through large population study.

Disclaimer

This material on this page is ©2024 American Society of Clinical Oncology, all rights reserved. Licensing available upon request. For more information, please contact licensing@asco.org

Abstract Details

Meeting

2017 ASCO Annual Meeting

Session Type

Publication Only

Session Title

Publication Only: <span>Cancer Prevention, Hereditary Genetics, and Epidemiology</span>

Track

Prevention, Risk Reduction, and Genetics

Sub Track

Cancer Genetics

Citation

J Clin Oncol 35, 2017 (suppl; abstr e13000)

DOI

10.1200/JCO.2017.35.15_suppl.e13000

Abstract #

e13000

Abstract Disclosures

Similar Abstracts

Abstract

2024 ASCO Quality Care Symposium

Assessing capacity for hereditary cancer risk assessment in metro Chicago.

First Author: Tamara Hamlish

First Author: Chinedu Ukaegbu