Management of patients with head and neck cancer (HNC) and synchronic stage I or II lung cancer. SYNCHRON GFPC 15-01 study.

Authors

null

Laurie Saramon

HNC Unit, CHRU Brest, Brest, France

Laurie Saramon , Nicolas Paleiron , Gilles Robinet , Radj Gervais , Pierre Fournel , Hervé Le Caer , Henri Berard , Olivier Bylicki , Jean Rousset , Gerald Valette , Christos Chouaid

Organizations

HNC Unit, CHRU Brest, Brest, France, Respiratory Disease Unit, HIA Clermont Tonnerre, Brest, France, CHU Morvan, Brest, France, CLCC Baclesse, Caen, France, GFPC (France), Institut de Cancérologie de la Loire, St. Priest En Jarez, France, Centre Hospitalier de Saint Brieuc, Saint-Brieuc, France, Hopital D'instruction Des Armes Sainte-Anne, Toulon, France, HIA Desgenettes, Ampuis, France, Radiology Unit, HIA Clermont Tonnerre, Brest, France, Head and Neck Surgery Department, University Hospital of Brest, Brest, France, Centre Hospitalier Intercommunal (CHI) Creteil, Créteil, France

Research Funding

Pharmaceutical/Biotech Company

Background: There is few published data’s of the management of patients with a HNC and a synchronic lung cancer. The aim of this observational study was to describe in a multicentric setting the management of these patients. Methods: The study included, consecutively all patients diagnosed between January 2011 and December 2015 in 19 French centers with a HNC and a synchronic lung cancer. Patients were described per the clinical characteristics, management and outcomes. Patient characteristics and treatment information was analyzed descriptively. Kaplan-Meier estimation was used to assess median overall survival. Results: The study included 62 patients: men : 84%; 62 ± 1.3 years old, current smokers: 68%, asbestos exposure: 11%; performans status: 0 and 1 for 22.5% and 66% of the patients respectively; hight rate of comorbidities, cardiovascular: 68%, COPD: 32%. Main histology for HNC was squamous: 98%, in oral cavity: 32%, oropharyngeal: 21%, hypo-pharyngeal: 22.5% and laryngeal: 24%. T classification was T1, T2, T3 and T4 in 18%, 29%, 29% and 16% of cases respectively, and N classification was N0, N1, N2, N3, for 40%, 24%, 21% and 6% of cases respectively. The main treatment was surgery, 47%, and chemo-radiotherapy, 52%. The diagnosis of lung cancer impacts the HNC management in 21% of the cases. Median delay between HNC and first day treatment was 54 ± 6 days. HNC progressive free survival rate was 68% at 2 years. Lung cancers were localized (stages I: 81%, stages II: 19%), squamous: 32%, adeno-carcinomas: 47%, larges cells or sarcomatosis: 7%. Main treatments were surgery: 56%, mainly lobectomy, radiotherapy: 15%, radio-chemotherapy: 10% and chemotherapy alone: 26%. Six patients didn’t receive active treatment. Median delay of treatment was 150 ± 16 days. Lung cancer progressive free survival rate was 28% at 2 years. OS was 55% at 2 years, better for stage I than stage II lung cancers. Conclusions: Synchronic lung cancer at HCN diagnosis impact management and outcomes of HNC with a delay in the management of lung cancer. Specific recommendations should be elaborate to improve the management of these patients.

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Abstract Details

Meeting

2017 ASCO Annual Meeting

Session Type

Publication Only

Session Title

Publication Only: Lung Cancer-Non-Small Cell Local-Regional/Small Cell/Other Thoracic Cancers

Track

Lung Cancer

Sub Track

Local-Regional Non–Small Cell Lung Cancer

Citation

J Clin Oncol 35, 2017 (suppl; abstr e20048)

DOI

10.1200/JCO.2017.35.15_suppl.e20048

Abstract #

e20048

Abstract Disclosures