A phase I study to assess the safety, pharmacokinetics (PK), pharmacodynamics (PD) and antitumor activities of daily oral BAL101553, a novel tumor checkpoint controller (TCC) in adult patients with progressive or recurrent glioblastoma (GBM) or high-grade glioma.

Authors

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Alvaro Henrique Ingles Garces

The Royal Marsden Hospital and The Institute of Cancer Research, London, United Kingdom

Alvaro Henrique Ingles Garces , Elizabeth R. Plummer , Juanita Suzanne Lopez , Rebecca Sophie Kristeleit , Julie MacDonald , Lorna Sweeting , Michael-John Devlin , Yvette Drew , Alison L. Hannah , Nicola Aceto , Stephanie Anderson , Heidi A Lane , Patrice Larger , Martina Maurer , Phil McKernan , Marc Frederick Engelhardt , Alastair Greystoke , Niamh Coleman , T.R. Jeffry Evans , Paul James Mulholland

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Poster Details

Meeting

2017 ASCO Annual Meeting

Session Type

Poster Session

Session Title

Developmental Therapeutics—Clinical Pharmacology and Experimental Therapeutics

Track

Developmental Therapeutics and Translational Research

Sub Track

Chemotherapy

Clinical Trial Registration Number

NCT02490800

Citation

J Clin Oncol 35, 2017 (suppl; abstr TPS2601)

DOI

10.1200/JCO.2017.35.15_suppl.TPS2601

Abstract #

TPS2601

Poster Bd #

90b

Abstract Disclosures