Interaction of 1970–2010 breast cancer in-situ (brca, DCIS) rates with invasive breast cancer (brcainv) and mortality (brcamor): Comparative analysis of two regions with different screening mammography and therapy guidelines (ScreenMam).

Authors

null

Joseph Ragaz

University of British Columbia School of Population and Public Health, North Vancouver, BC, Canada

Joseph Ragaz , Joel Fox , Shayan Shakeraneh , Kenneth S. Wilson , Hong Qian , Hubert Wong

Organizations

University of British Columbia School of Population and Public Health, North Vancouver, BC, Canada, Medical School, University Of British Columbia, Vancouver, BC, Canada, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada, British Columbia Cancer Agency, Victoria, BC, Canada, 4.Centre for Health Evaluation and Outcome Sciences, Providence Health Care Research Institute, St. Paul's Hospital, University of B.C., Vancouver, BC, Canada, School of Population and Public Health, and Centre for Health Evaluation and Outcome Sciences, Providence Health Care Research Institute, St. Paul's Hospital, University British Columbia, Vancouver, BC, Canada

Research Funding

Other

Background: To correlate age-standardized rates [ASRs] of DCIS, BrCaINV and BrCaMOR, separately for ages <50 vs >50. British Columbia [BC] is known for earlier introduction, tighter adherence to, and more uniformity of ScreenMam than the Atlantic Provinces [AP]. Methods: Annual age-specific rates [ASRs] of DCIS, BrCaINV, and BrCaMOR were obtained for 17 five-year age groups (years 0-4 to 85+) in BC and AP, and averaged over 5-year1970-1974 to 2005-2009 periods [Lustrum], separately for ages <50 and >50. BrCaINV and BrCaMOR rates were expressed in percentages, relative to 1970-74 average. Data were obtained from Canada Public Health Agency and Canada Ca Registry database at Statistics Canada. Results: See Tables. Conclusions: DCIS: Rates are substantially increased since 1970s in both regions. For ages >50, rate stabilization is seen after 2000s, particularly in BC where the rate decrease is seen after 2005. BrCaINV: In both regions, rates for ages <50 have been stable. For ages >50, rates are initially increasing and then decreasing, with reduction observed to a lower extent in BC, and much earlier than in AP BrCaMOR: For both age groups, rate decrease is more substantial in BC than AP. Difference is particularly evident for ages >50, with reduction in BC observed at least a decade earlier, and to a much lower degree. SUMMARY: Levelling or decrease of DCIS rates in regions with more adherent ScreenMam is a new observation which may antedate a more substantial delayed rate reduction of both BrCaINV and BrCaMOR. Earlier diagnosis & therapy of less resistant BrCa lesions, as enabled by ScreenMam, are the likely causes for these outcome improvements.

Age < 50.

DCISBrCaINV [%]BrCaMOR [%]
LustrumBCAPBCAPBCAP
1980-841.70.991968990
1985-893.31.495998894
1990-943.82.5951048286
1995-994.52.9891097180
2000-044.93.4871015363
2005-095.43.6901034953

Age > 50.

DCISBrCaINV [%]BrCaMOR [%]
LustrumBCAPBCAPBCAP
1980-8411.16.8103109100108
1985-8923.09.9119126101103
1990-9432.219.712414295118
1995-9945.231.812114986113
2000-0446.438.11071427194
2005-0944.940.01061386478

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Abstract Details

Meeting

2016 ASCO Annual Meeting

Session Type

Publication Only

Session Title

Publication Only:  Cancer Prevention, Hereditary Genetics, and Epidemiology

Track

Prevention, Risk Reduction, and Genetics

Sub Track

Etiology/Epidemiology

Citation

J Clin Oncol 34, 2016 (suppl; abstr e13069)

DOI

10.1200/JCO.2016.34.15_suppl.e13069

Abstract #

e13069

Abstract Disclosures

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