Background: The cost of cancer care in the U.S. is projected to reach $158 billion by 2020. The ASCO Value in Cancer Care Task Force recently released a framework assessing the value of new cancer therapies based on benefits, toxicities, and costs. Reducing under and over-screening can improve the quality of cancer care while also reducing costs. Multiple studies have shown that adherence to U.S. Preventative Services Task Force (USPSTF) screening guidelines remains sub-optimal. We tested whether distributing a low-cost educational tool consisting of a Health Maintenance (HM) card among house staff of a large teaching hospital would impact adherence to updated cancer screening guidelines. We also calculated the potential impact on health care expenditure from this intervention. Methods: In January 2013, HM cards with USPSTF recommendations were posted in each Ambulatory Medicine clinic exam room. We assessed the adherence to screening guidelines by comparing a historical control of clinic visits from December 2012 (n = 336) to those from December 2013; a year after the intervention (n = 306). In order to calculate charges associated with screening procedures, Center for Medicare and Medicaid Services’ Physician Fee Schedule was used. Results: Adherence to USPSTF guidelines showed a significant increase of 40.8% (p < 0.01) for cervical, 33.2% (p < 0.01) for breast and 20.5% (p < 0.01) for colorectal cancer screening. Inappropriate screening actions were reduced by 26.8% (p < 0.01) for cervical and 32.8% (p < 0.01) for breast cancer. A non-significant 1.1% increase (p = 0.829) was observed for colorectal cancer. Based on the number of inappropriate screening procedures averted, we calculated annualized potential savings to the healthcare system amounting to $1,138,464 (95% CI; $680,640 - $1,597,140). Conclusions: The low-cost HM card increased appropriate cancer screening while reducing unnecessary testing and producing substantial savings to the healthcare system in a large urban cohort. In an era of expensive personalized cancer care, low cost-interventions to improve the quality of care delivery may help mitigate the burden on the health care system.