Background: Parents of children with cancer desire information on late effects of treatment. In a prior study conducted at diagnosis, we found that parents felt they received better quality information about treatment than about late effects. Methods: We conducted a cross-sectional survey of parents of children with cancer at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center at least 5 years after diagnosis; all parents had previously participated in a study about communication at diagnosis. In this follow-up study, 65% of parents of children who were still living, and whom we were able to contact, participated (n = 90). 77% of respondents (n = 69) were parents of disease-free survivors; 23% (n = 21) were parents of children with relapsed disease. We assessed parental preparedness for cancer care and late effects of treatment. Results: Most parents reported feeling extremely or very well prepared for their child’s pediatric oncology treatment (86%), daily care needs during treatment (85%), and for the chance of their child being cured (87%). Compared with preparation for treatment, fewer parents felt extremely or very well prepared for future limitations experienced by their children (63/88 = 72%, McNemar’s Test p = 0.003) or for life after cancer (42/66 = 64%, p < 0.001). In bivariable analysis among parents of disease-free survivors, parents were more likely to feel prepared for future limitations when they believed their child had no limitations in quality of life (OR 4.00, 95% CI 1.32, 12.1; p = 0.01), and when they felt that communication with their child’s oncologist had helped them deal with worries about the future (OR 4.38, 95% CI 1.31, 14.7; p = 0.02). Conclusions: Parents feel prepared to manage their child’s cancer treatment, but they feel less prepared for survivorship. High quality communication with providers may help parents feel more prepared for life after cancer therapy.