Dosimetric study of 3-dimensional conformal radiotherapy, electronic compensator technique, intensity modulated radiation therapy, and volumetric arc therapy in whole-breast irradiation.

Authors

null

Chonnipa Nantavithya

King Chulalongkorn Memorial Hospital, Bangkok, Thailand

Organizations

King Chulalongkorn Memorial Hospital, Bangkok, Thailand

Research Funding

No funding sources reported

Background: Whole breast irradiation is an essential treatment after breast conserving surgery (BCS). Adverse effects are from inhomogeneity of PTV and excessive dose to normal tissues. Aim of this study is to compare dosimetry among standard technique, three-dimensional Conformal Radiotherapy (3D-CRT) and advanced techniques, Electronic Compensator (ECOMP), Intensity Modulated Radiation Therapy (IMRT) and Volumetric Arc Therapy (VMAT). Methods: Images from CT simulation of patients who underwent BCS were replanned. Clinical Target Volume (CTV) was contoured followed RTOG atlas as breast only and breast with chest wall respectively. Planning Target Volume (PTV) was expanded 0.7 cm from CTV. Each patient was replanned with all four techniques. Dose prescription was 50 Gy in 25 fractions. Results: Twenty five patients underwent CT simulation from November 2013 to November 2014 were included. Six patients with node positive were planned for breast with chest wall irradiation and 19 patients with node negative were planned for breast only irradiation. Primary outcome, homogeneity index (HI) of 3D-CRT, ECOMP, IMRT and VMAT were 0.865, 0.889, 0.890 and 0.866 respectively which ECOMP and IMRT were significant higher than 3D-CRT (p values < 0.001). Secondary outcome, conformity index (CI), Mean heart dose (MHD), heart V25, heart V30, mean lung dose (MLD), mean ipsilaterallung dose (MILD), mean contralateral lung dose (MCLD) and mean contralateral breast dose (MCBD) of advanced techniques were significant better than 3D-CRT technique. Conclusions: HI of ECOMP and IMRT were statistically significant higher compared with 3D-CRT technique. Advanced techniques showed statistically significant superior in CI dose to heart, lungs and contralateral breast.

Disclaimer

This material on this page is ©2024 American Society of Clinical Oncology, all rights reserved. Licensing available upon request. For more information, please contact licensing@asco.org

Abstract Details

Meeting

2015 Breast Cancer Symposium

Session Type

Poster Session

Session Title

Poster Session A: Risk Assessment, Prevention, Early Detection, Screening, and Local/Regional Therapy

Track

Local/Regional Therapy,Systemic Therapy,Risk Assessment, Prevention, Early Detection, and Screening

Sub Track

Biology in Local/Regional Management

Citation

J Clin Oncol 33, 2015 (suppl 28S; abstr 44)

DOI

10.1200/jco.2015.33.28_suppl.44

Abstract #

44

Poster Bd #

G4

Abstract Disclosures

Similar Abstracts