Background: Our aim was to evaluate the significance of serum inflammatory markers including serum C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), neutrophil lymphocyte ratio (NLR) and serum albumin level in predicting prognosis in patients with gastric cancer and to evaluate relationship between inflammatory markers and clinicopathologic characteristics. Methods: The study population consisted of 53 advanced gastric cancer patients. The systemic inflammatory markers including CRP, ESR, albumin and NLR in addition to clinical and tumor-releated factors were recorded. Patients were classified into 2 groups based on median levels of each marker (group 1: patients with serum marker ≤ median level, group 2: patients with serum marker > median level). The relationship between inflammatory markers and the clinicopathologic parameters were assessed via chi square test. The association of each marker with survival was analyzed using the log-rank test. Multivariate analyses were carried out using the Cox proportional hazard model. Results: Twenty one percent of patients was female and 81% was male with a median age of 65 years (min-max: 37-87). Twenty two patients had stage IV disease and 28 patients had tumor load. All analysed inflammatory parameters were statistically significantly higher in patients with tumor load than those without (p<0.05). ESR did not correlate with distant metastasis in contrast to CRP, serum albumin and NLR. In univariate analysis, serum albumin, CRP, and NLR levels were useful prognostic biomarker for predicting progression free survival (PFS) and overall survival (OS). In multivariate analysis, only serum albumin was found to be prognostic for PFS (p =0.05; HR: 4.735; 95% CI: 0.966-23.202), but none of the studied inflammatory markers were found to be significant for OS. Conclusions: This study demonstrates that gastric cancer patients with low serum albumin level, high CRP, high ESR and high NLR may have tumor load. In addition, patients with high CRP levels should be evaluated for distant metastasis. Serum albumin level may be the most useful inflammatory biomarker predicting prognosis of gastric cancer.